We present Saguaro, a permissioned blockchain system designed specifically for edge computing networks. Saguaro leverages the hierarchical structure of edge computing networks to reduce the overhead of wide-area communication by presenting several techniques. First, Saguaro proposes coordinator-based and optimistic protocols to process cross-domain transactions with low latency where the lowest common ancestor of the involved domains coordinates the protocol or detects inconsistency. Second, data are collected over hierarchy enabling higher-level domains to aggregate their sub-domain data. Finally, transactions initiated by mobile edge devices are processed without relying on high-level fog and cloud servers. Our experimental results across a wide range of workloads demonstrate the scalability of Saguaro in supporting a range of cross-domain and mobile transactions.