Revelations of large scale electronic surveillance and data mining by governments and corporations have fueled increased adoption of HTTPS. We present a traffic analysis attack against over 6000 webpages spanning the HTTPS deployments of 10 widely used, industry-leading websites in areas such as healthcare, finance, legal services and streaming video. Our attack identifies individual pages in the same website with 89% accuracy, exposing personal details including medical conditions, financial and legal affairs and sexual orientation. We examine evaluation methodology and reveal accuracy variations as large as 18% caused by assumptions affecting caching and cookies. We present a novel defense reducing attack accuracy to 27% with a 9% traffic increase, and demonstrate significantly increased effectiveness of prior defenses in our evaluation context, inclusive of enabled caching, user-specific cookies and pages within the same website.