Resource constrained Internet-of-Things (IoT) devices are highly likely to be compromised by attackers because strong security protections may not be suitable to be deployed. This requires an alternative approach to protect vulnerable components in IoT networks. In this paper, we propose an integrated defense technique to achieve intrusion prevention by leveraging cyberdeception (i.e., a decoy system) and moving target defense (i.e., network topology shuffling). We verify the effectiveness and efficiency of our proposed technique analytically based on a graphical security model in a software defined networking (SDN)-based IoT network. We develop four strategies (i.e., fixed/random and adaptive/hybrid) to address "when" to perform network topology shuffling and three strategies (i.e., genetic algorithm/decoy attack path-based optimization/random) to address "how" to perform network topology shuffling on a decoy-populated IoT network, and analyze which strategy can best achieve a system goal such as prolonging the system lifetime, maximizing deception effectiveness, maximizing service availability, or minimizing defense cost. Our results demonstrate that a software defined IoT network running our intrusion prevention technique at the optimal parameter setting prolongs system lifetime, increases attack complexity of compromising critical nodes, and maintains superior service availability compared with a counterpart IoT network without running our intrusion prevention technique. Further, when given a single goal or a multi-objective goal (e.g., maximizing the system lifetime and service availability while minimizing the defense cost) as input, the best combination of "how" and "how" strategies is identified for executing our proposed technique under which the specified goal can be best achieved.