Binary Code Similarity Detection (BCSD) is significant for software security as it can address binary tasks such as malicious code snippets identification and binary patch analysis by comparing code patterns. Recently, there has been a growing focus on artificial intelligence-based approaches in BCSD due to their scalability and generalization. Because binaries are compiled with different compilation configurations, existing approaches still face notable limitations when comparing binary similarity. First, BCSD requires analysis on code behavior, and existing work claims to extract semantic, but actually still makes analysis in terms of syntax. Second, directly extracting features from assembly sequences, existing work cannot address the issues of instruction reordering and different syntax expressions caused by various compilation configurations. In this paper, we propose StrTune, which slices binary code based on data dependence and perform slice-level fine-tuning. To address the first limitation, StrTune performs backward slicing based on data dependence to capture how a value is computed along the execution. Each slice reflects the collecting semantics of the code, which is stable across different compilation configurations. StrTune introduces flow types to emphasize the independence of computations between slices, forming a graph representation. To overcome the second limitation, based on slices corresponding to the same value computation but having different syntax representation, StrTune utilizes a Siamese Network to fine-tune such pairs, making their representations closer in the feature space.