Consider the task of learning a hypothesis class $\mathcal{H}$ in the presence of an adversary that can replace up to an $η$ fraction of the examples in the training set with arbitrary adversarial examples. The adversary aims to fail the learner on a particular target test point $x$ which is known to the adversary but not to the learner. In this work we aim to characterize the smallest achievable error $ε=ε(η)$ by the learner in the presence of such an adversary in both realizable and agnostic settings. We fully achieve this in the realizable setting, proving that $ε=Θ(\mathtt{VC}(\mathcal{H})\cdot η)$, where $\mathtt{VC}(\mathcal{H})$ is the VC dimension of $\mathcal{H}$. Remarkably, we show that the upper bound can be attained by a deterministic learner. In the agnostic setting we reveal a more elaborate landscape: we devise a deterministic learner with a multiplicative regret guarantee of $ε\leq C\cdot\mathtt{OPT} + O(\mathtt{VC}(\mathcal{H})\cdot η)$, where $C > 1$ is a universal numerical constant. We complement this by showing that for any deterministic learner there is an attack which worsens its error to at least $2\cdot \mathtt{OPT}$. This implies that a multiplicative deterioration in the regret is unavoidable in this case. Finally, the algorithms we develop for achieving the optimal rates are inherently improper. Nevertheless, we show that for a variety of natural concept classes, such as linear classifiers, it is possible to retain the dependence $ε=Θ_{\mathcal{H}}(η)$ by a proper algorithm in the realizable setting. Here $Θ_{\mathcal{H}}$ conceals a polynomial dependence on $\mathtt{VC}(\mathcal{H})$.