Decentralized finance, i.e., DeFi, has become the most popular type of application on many public blockchains (e.g., Ethereum) in recent years. Compared to the traditional finance, DeFi allows customers to flexibly participate in diverse blockchain financial services (e.g., lending, borrowing, collateralizing, exchanging etc.) via smart contracts at a relatively low cost of trust. However, the open nature of DeFi inevitably introduces a large attack surface, which is a severe threat to the security of participants funds. In this paper, we proposed BLOCKEYE, a real-time attack detection system for DeFi projects on the Ethereum blockchain. Key capabilities provided by BLOCKEYE are twofold: (1) Potentially vulnerable DeFi projects are identified based on an automatic security analysis process, which performs symbolic reasoning on the data flow of important service states, e.g., asset price, and checks whether they can be externally manipulated. (2) Then, a transaction monitor is installed offchain for a vulnerable DeFi project. Transactions sent not only to that project but other associated projects as well are collected for further security analysis. A potential attack is flagged if a violation is detected on a critical invariant configured in BLOCKEYE, e.g., Benefit is achieved within a very short time and way much bigger than the cost. We applied BLOCKEYE in several popular DeFi projects and managed to discover potential security attacks that are unreported before. A video of BLOCKEYE is available at https://youtu.be/7DjsWBLdlQU.