We present Low*, a language for low-level programming and verification, and its application to high-assurance optimized cryptographic libraries. Low* is a shallow embedding of a small, sequential, well-behaved subset of C in F*, a dependently-typed variant of ML aimed at program verification. Departing from ML, Low* does not involve any garbage collection or implicit heap allocation; instead, it has a structured memory model à la CompCert, and it provides the control required for writing efficient low-level security-critical code. By virtue of typing, any Low* program is memory safe. In addition, the programmer can make full use of the verification power of F* to write high-level specifications and verify the functional correctness of Low* code using a combination of SMT automation and sophisticated manual proofs. At extraction time, specifications and proofs are erased, and the remaining code enjoys a predictable translation to C. We prove that this translation preserves semantics and side-channel resistance. We provide a new compiler back-end from Low* to C and, to evaluate our approach, we implement and verify various cryptographic algorithms, constructions, and tools for a total of about 28,000 lines of code, specification and proof. We show that our Low* code delivers performance competitive with existing (unverified) C cryptographic libraries, suggesting our approach may be applicable to larger-scale low-level software.