Blockchain and distributed ledger technologies are gaining the interest of the academy, companies, and institutions. Nonetheless, the path toward blockchain adoption is not straightforward, as blockchain is a complex technology that requires revisiting the standard way of addressing problems and tackling them from a decentralized perspective. Thus, decision-makers adopt blockchain technology for the wrong reasons or prefer it to more suitable ones. This work presents a decision framework for blockchain adoption to help decision-makers decide whether blockchain is applicable, valuable, and preferable to other technologies. In particular, The decision framework is composed of a small set of questions that can be answered from a managerial standpoint and that do not require a deep technical knowledge of blockchain-related topics.