Attackers utilize a plethora of adversarial techniques in cyberattacks to compromise the confidentiality, integrity, and availability of the target organizations and systems. Information security standards such as NIST, ISO/IEC specify hundreds of security controls that organizations can enforce to protect and defend the information systems from adversarial techniques. However, implementing all the available controls at the same time can be infeasible and security controls need to be investigated in terms of their mitigation ability over adversarial techniques used in cyberattacks as well. The goal of this research is to aid organizations in making informed choices on security controls to defend against cyberthreats through an investigation of adversarial techniques used in current cyberattacks. In this study, we investigated the extent of mitigation of 298 NIST SP800-53 controls over 188 adversarial techniques used in 669 cybercrime groups and malware cataloged in the MITRE ATT\&CK framework based upon an existing mapping between the controls and techniques. We identify that, based on the mapping, only 101 out of 298 control are capable of mitigating adversarial techniques. However, we also identify that 53 adversarial techniques cannot be mitigated by any existing controls, and these techniques primarily aid adversaries in bypassing system defense and discovering targeted system information. We identify a set of 20 critical controls that can mitigate 134 adversarial techniques, and on average, can mitigate 72\% of all techniques used by 98\% of the cataloged adversaries in MITRE ATT\&CK. We urge organizations, that do not have any controls enforced in place, to implement the top controls identified in the study.