ML-as-a-service continues to grow, and so does the need for very strong privacy guarantees. Secure inference has emerged as a potential solution, wherein cryptographic primitives allow inference without revealing users' inputs to a model provider or model's weights to a user. For instance, the model provider could be a diagnostics company that has trained a state-of-the-art DenseNet-121 model for interpreting a chest X-ray and the user could be a patient at a hospital. While secure inference is in principle feasible for this setting, there are no existing techniques that make it practical at scale. The CrypTFlow2 framework provides a potential solution with its ability to automatically and correctly translate clear-text inference to secure inference for arbitrary models. However, the resultant secure inference from CrypTFlow2 is impractically expensive: Almost 3TB of communication is required to interpret a single X-ray on DenseNet-121. In this paper, we address this outstanding challenge of inefficiency of secure inference with three contributions. First, we show that the primary bottlenecks in secure inference are large linear layers which can be optimized with the choice of network backbone and the use of operators developed for efficient clear-text inference. This finding and emphasis deviates from many recent works which focus on optimizing non-linear activation layers when performing secure inference of smaller networks. Second, based on analysis of a bottle-necked convolution layer, we design a X-operator which is a more efficient drop-in replacement. Third, we show that the fast Winograd convolution algorithm further improves efficiency of secure inference. In combination, these three optimizations prove to be highly effective for the problem of X-ray interpretation trained on the CheXpert dataset.