Advanced Persistent Threat (APT) attacks have caused significant damage worldwide. Various Endpoint Detection and Response (EDR) systems are deployed by enterprises to fight against potential threats. However, EDR suffers from high false positives. In order not to affect normal operations, analysts need to investigate and filter detection results before taking countermeasures, in which heavy manual labor and alarm fatigue cause analysts miss optimal response time, thereby leading to information leakage and destruction. Therefore, we propose Endpoint Forecasting and Interpreting (EFI), a real-time attack forecast and interpretation system, which can automatically predict next move during post-exploitation and explain it in technique-level, then dispatch strategies to EDR for advance reinforcement. First, we use Cyber Threat Intelligence (CTI) reports to extract the attack scene graph (ASG) that can be mapped to low-level system logs to strengthen attack samples. Second, we build a serialized graph forecast model, which is combined with the attack provenance graph (APG) provided by EDR to generate an attack forecast graph (AFG) to predict the next move. Finally, we utilize the attack template graph (ATG) and graph alignment plus algorithm for technique-level interpretation to automatically dispatch strategies for EDR to reinforce system in advance. EFI can avoid the impact of existing EDR false positives, and can reduce the attack surface of system without affecting the normal operations. We collect a total of 3,484 CTI reports, generate 1,429 ASGs, label 8,000 sentences, tag 10,451 entities, and construct 256 ATGs. Experimental results on both DARPA Engagement and large scale CTI dataset show that the alignment score between the AFG predicted by EFI and the real attack graph is able to exceed 0.8, the forecast and interpretation precision of EFI can reach 91.8%.