Backdoor attacks have emerged as an urgent threat to Deep Neural Networks (DNNs), where victim DNNs are furtively implanted with malicious neurons that could be triggered by the adversary. To defend against backdoor attacks, many works establish a staged pipeline to remove backdoors from victim DNNs: inspecting, locating, and erasing. However, in a scenario where a few clean data can be accessible, such pipeline is fragile and cannot erase backdoors completely without sacrificing model accuracy. To address this issue, in this paper, we propose a novel data-free holistic backdoor erasing (DHBE) framework. Instead of the staged pipeline, the DHBE treats the backdoor erasing task as a unified adversarial procedure, which seeks equilibrium between two different competing processes: distillation and backdoor regularization. In distillation, the backdoored DNN is distilled into a proxy model, transferring its knowledge about clean data, yet backdoors are simultaneously transferred. In backdoor regularization, the proxy model is holistically regularized to prevent from infecting any possible backdoor transferred from distillation. These two processes jointly proceed with data-free adversarial optimization until a clean, high-accuracy proxy model is obtained. With the novel adversarial design, our framework demonstrates its superiority in three aspects: 1) minimal detriment to model accuracy, 2) high tolerance for hyperparameters, and 3) no demand for clean data. Extensive experiments on various backdoor attacks and datasets are performed to verify the effectiveness of the proposed framework. Code is available at \url{https://github.com/yanzhicong/DHBE}