The growing reliance on data-driven applications in sectors such as healthcare, finance, and law enforcement underscores the need for secure, privacy-preserving, and scalable mechanisms for data generation and sharing. Synthetic data generation (SDG) has emerged as a promising approach but often relies on centralized or external processing, raising concerns about data sovereignty, domain ownership, and compliance with evolving regulatory standards. To overcome these issues, we introduce SynthGuard, a framework designed to ensure computational governance by enabling data owners to maintain control over SDG workflows. SynthGuard supports modular and privacy-preserving workflows, ensuring secure, auditable, and reproducible execution across diverse environments. In this paper, we demonstrate how SynthGuard addresses the complexities at the intersection of domain-specific needs and scalable SDG by aligning with requirements for data sovereignty and regulatory compliance. Developed iteratively with domain expert input, SynthGuard has been validated through real-world use cases, demonstrating its ability to balance security, privacy, and scalability while ensuring compliance. The evaluation confirms its effectiveness in implementing and executing SDG workflows and integrating privacy and utility assessments across various computational environments.