In recent years, smart contracts have suffered major exploits, costing millions of dollars. Unlike traditional programs, smart contracts are deployed on a blockchain. As such, they cannot be modified once deployed. Though various tools have been proposed to detect vulnerable smart contracts, the majority fails to protect vulnerable contracts that have already been deployed on the blockchain. Only very few solutions have been proposed so far to tackle the issue of post-deployment. However, these solutions suffer from low precision and are not generic enough to prevent any type of attack. In this work, we introduce ÆGIS, a dynamic analysis tool that protects smart contracts from being exploited during runtime. Its capability of detecting new vulnerabilities can easily be extended through so-called attack patterns. These patterns are written in a domain-specific language that is tailored to the execution model of Ethereum smart contracts. The language enables the description of malicious control and data flows. In addition, we propose a novel mechanism to streamline and speed up the process of managing attack patterns. Patterns are voted upon and stored via a smart contract, thus leveraging the benefits of tamper-resistance and transparency provided by the blockchain. We compare ÆGIS to current state-of-the-art tools and demonstrate that our solution achieves higher precision in detecting attacks. Finally, we perform a large-scale analysis on the first 4.5 million blocks of the Ethereum blockchain, thereby confirming the occurrences of well reported and yet unreported attacks in the wild.