State-of-the-art machine learning models are vulnerable to data poisoning attacks whose purpose is to undermine the integrity of the model. However, the current literature on data poisoning attacks is mainly focused on ad hoc techniques that are only applicable to specific machine learning models. Additionally, the existing data poisoning attacks in the literature are limited to either binary classifiers or to gradient-based algorithms. To address these limitations, this paper first proposes a novel model-free label-flipping attack based on the multi-modality of the data, in which the adversary targets the clusters of classes while constrained by a label-flipping budget. The complexity of our proposed attack algorithm is linear in time over the size of the dataset. Also, the proposed attack can increase the error up to two times for the same attack budget. Second, a novel defense technique based on the Synthetic Reduced Nearest Neighbor (SRNN) model is proposed. The defense technique can detect and exclude flipped samples on the fly during the training procedure. Through extensive experimental analysis, we demonstrate that (i) the proposed attack technique can deteriorate the accuracy of several models drastically, and (ii) under the proposed attack, the proposed defense technique significantly outperforms other conventional machine learning models in recovering the accuracy of the targeted model.