Detecting unseen ransomware is a critical cybersecurity challenge where classical machine learning often fails. While Quantum Machine Learning (QML) presents a potential alternative, its application is hindered by the dimensionality gap between classical data and quantum hardware. This paper empirically investigates a hybrid framework using a Variational Quantum Classifier (VQC) interfaced with a high-dimensional dataset via Principal Component Analysis (PCA). Our analysis reveals a dual challenge for practical QML. A significant information bottleneck was evident, as even the best performing 12-qubit VQC fell short of the classical baselines 97.7\% recall. Furthermore, a non-monotonic performance trend, where performance degraded when scaling from 4 to 8 qubits before improving at 12 qubits suggests a severe trainability issue. These findings highlight that unlocking QMLs potential requires co-developing more efficient data compression techniques and robust quantum optimization strategies.