The rapid advancement of Artificial Intelligence has enabled the development of cruise missiles endowed with high levels of autonomy, adaptability, and precision. These AI driven missiles integrating deep learning algorithms, real time data processing, and advanced guidance systems pose critical threats to strategic infrastructures, especially under complex geographic and climatic conditions such as those found in Irans Khuzestan Province. In this paper, we propose a multi layer interference model, encompassing electronic warfare, cyberattacks, and deception strategies, to degrade the performance of AI guided cruise missiles significantly. Our experimental results, derived from 400 simulation runs across four distinct scenarios, demonstrate notable improvements when employing the integrated multi layer approach compared to single layer or no interference baselines. Specifically, the average missile deviation from its intended target increases from 0.25 to 8.65 under multi layer interference a more than 3300 increase in angular deviation. Furthermore, the target acquisition success rate is reduced from 92.7 in the baseline scenario to 31.5, indicating a 66 decrease in successful strikes. While resource consumption for multi layer strategies rises by approximately 25 compared to single layer methods, the significant drop in missile accuracy and reliability justifies the more intensive deployment of jamming power, cyber resources, and decoy measures. Beyond these quantitative improvements, the proposed framework uses a deep reinforcement learning based defense coordinator to adaptively select the optimal configuration of EW, cyber, and deception tactics in real time.