As a result of decades of research, Windows malware detection is approached through a plethora of techniques. However, there is an ongoing mismatch between academia -- which pursues an optimal performances in terms of detection rate and low false alarms -- and the requirements of real-world scenarios. In particular, academia focuses on combining static and dynamic analysis within a single or ensemble of models, falling into several pitfalls like (i) firing dynamic analysis without considering the computational burden it requires; (ii) discarding impossible-to-analyze samples; and (iii) analyzing robustness against adversarial attacks without considering that malware detectors are complemented with more non-machine-learning components. Thus, in this paper we bridge these gaps, by investigating the properties of malware detectors built with multiple and different types of analysis. To do so, we develop SLIFER, a Windows malware detection pipeline sequentially leveraging both static and dynamic analysis, interrupting computations as soon as one module triggers an alarm, requiring dynamic analysis only when needed. Contrary to the state of the art, we investigate how to deal with samples that impede analyzes, showing how much they impact performances, concluding that it is better to flag them as legitimate to not drastically increase false alarms. Lastly, we perform a robustness evaluation of SLIFER. Counter-intuitively, the injection of new content is either blocked more by signatures than dynamic analysis, due to byte artifacts created by the attack, or it is able to avoid detection from signatures, as they rely on constraints on file size disrupted by attacks. As far as we know, we are the first to investigate the properties of sequential malware detectors, shedding light on their behavior in real production environment.