Ever increasing number of Android malware, has always been a concern for cybersecurity professionals. Even though plenty of anti-malware solutions exist, a rational and pragmatic approach for the same is rare and has to be inspected further. In this paper, we propose a novel two-set feature selection approach based on Rough Set and Statistical Test named as RSST to extract relevant system calls. To address the problem of higher dimensional attribute set, we derived suboptimal system call space by applying the proposed feature selection method to maximize the separability between malware and benign samples. Comprehensive experiments conducted on a dataset consisting of 3500 samples with 30 RSST derived essential system calls resulted in an accuracy of 99.9%, Area Under Curve (AUC) of 1.0, with 1% False Positive Rate (FPR). However, other feature selectors (Information Gain, CFsSubsetEval, ChiSquare, FreqSel and Symmetric Uncertainty) used in the domain of malware analysis resulted in the accuracy of 95.5% with 8.5% FPR. Besides, empirical analysis of RSST derived system calls outperform other attributes such as permissions, opcodes, API, methods, call graphs, Droidbox attributes and network traces.