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Jay-Z unleashed a scathing freestyle aimed at Drake, Kanye West, Nicki Minaj and more during his headlining show at the Roots Picnic in Philadelphia.

When rapping about the “Anaconda” emcee, Jay — born Shawn Carter — said: “That lady back on the stuff, she sound like she in love with ’em / Her Ken[neth Petty] can’t even … Take they kids … *Tch* enough of them.” [Nicki is married to Kenneth Petty, who was convicted of attempted rape in the first degree for an assault of a then-16-year-old girl.]

“A rapper can’t be my opp, I got MAGA Republicans / Them shots came from the very top of the government, good luck with them,” he rapped. [Nicki, 43, recently came out as a supporter of President Donald Trump.]

Jay, 56, also hit back at Drake — born Aubrey Graham — who recently dissed the Roc Nation founder multiple times on his new albums.

On “Janice STFU,” the “Hotline Bling” rapper, 39, said: “We know how you OGs rocking already, my n–a, the jig is up.”

In response, Jay rapped Saturday: “The jig is up, n–a I’m up 10 / wrong chart champ, n–as looked up to Hov, I never looked up to them.” [Per Billboard, Drake’s album “ICEMAN” going No. 1 pushed him ahead of Jay for the most No. 1’s among solo men and R&B/hip-hop artists.]

When talking about West, Jay said: “You ever heard of wonder-kin? My children are some of them / Have you n–as have no shame? You really wanna get under my skin? / I’ll really get under ya skin (stab), ask Un how I’m playing.”

“Y’all thugs with y’all thumb again, everybody thinks they’re the ones insane / You’re no maniac, watch how he sane he acts in my presence, n–as shrink,” the “Empire State of Mind” rapper, 56, added.

As Page Six previously reported, last March, West, 48, attacked Beyoncé and Jay’s youngest two children in an unprovoked rant online, questioning their mental capacity.

Page Six has reached out to reps for Nicki and Ye for comment but did not immediately hear back.

Drake’s rep declined to comment.