Jacob Misiorowski was on a roll until he suddenly wasn’t.

The Brewers’ phenom looked like he was convincingly on his way to a no-hitter in Washington D.C. on Friday night. That was until the sixth inning.

With one out, Misiorowski threw a first-pitch strike to Nationals’ James Wood and was abruptly pulled from the game with a right hamstring cramp.

It was his 85th pitch that came on the heels of four consecutive strikeouts.

The 24-year-old, who didn’t appear to be in any pain, called for a trainer and the Brewers confirmed the cramp a few minutes later.

Jacob Misiorowski exits his start after 5.1 no-hit innings. The broadcast suspects it's a cramp or lower-half injury of some sort pic.twitter.com/CeTOoc1PKK

— Talkin' Baseball (@TalkinBaseball_) May 2, 2026

With the Brewers leading 4-0, he walked off after 5 1/3 hitless innings, striking out eight and walking two Nationals until that point.  

Milwaukee called in Aaron Ashby, who continued the no-hitter through the sixth inning, but lost it in the seventh on a double from Daylen Lile.

Manager Pat Murphy addressed the All-Star’s injury after the Brewers’ 6-1 win.

“We feel pretty good about it,” Murphy said. “We’re not going to test it right now because we’re afraid he might cramp again, so we’ll see what it is tomorrow.”

It seems the Brewers avoided anything serious, which is a relief for a team that just placed two-time All-Star starter Brandon Woodruff on the injured list due to shoulder inflammation after leaving his Thursday start early in the second inning.

Beyond Misiorowski and Woodruff, the Brewers have Kyle Harrison, Chad Patrick and Brandon Sproat in the rotation. Quinn Priester is currently on a minor-league rehab assisgnment while Logan Henerson is in the minors with the need to prove himself as big-league worthy.

They have some depth, but it would hurt the Brewers (17-14) if both Woodruff and Misiorowski needed to miss time.

Misiorowski, who is in his second season, holds a 2.84 ERA through seven starts with 59 strikeouts, which leads MLB this season. He is among the top early contenders for the NL Cy Young award.