Christina Applegate’s pals and former co-stars like Ed O’Neill and Katey Sagal are reportedly “anguished” over the actress’ health after her recent hospitalization — so much so that they’ve reached out to her.

“They don’t think this is it for her, she’s not dying right now. But they wanted to make sure that nothing was left unsaid,” a source close with Applegate and who worked on “Married… With Children” told the Daily Mail in an interview published Friday.

“They told each other that they love each other.”

Also among the list of celebrities who reportedly reached out with words of support were her “Dead to Me” co-star Linda Cardellini, her “Anchorman” costar Will Ferrell and Jean Smart, who played her mother in 2007’s “Samantha Who?”

Though, the message from O’Neill — who played her father on “Married… With Children” — held a significant meaning for Applegate as the pair remain close.

“I don’t want to say that Ed is a father figure to her, but they have kept in touch since their ‘Married with Children’ days and they are very, very close,” an insider close to O’Neill shared.

“They always have been. They text, they see each other, they call on the phone.”

The source added: “He heard the news that she was hospitalized and he immediately texted her and asked if he could help, told her he loved her, that he was here for her in any way that she needs.”

O’Neill is “anguished” and “so worried about her,” the source continued.

“He loves her very much. Obviously it’s not like she’s on her deathbed, I don’t think, but she’s not doing well and anything can happen,” said the insider.

“He hates to see her suffering, that really gets to him. So he’s offered whatever he can do to help. He’s family to her.”

Reps for Applegate, O’Neill and Sagal did not immediately respond to Page Six’s requests for comment.

Applegate, who was diagnosed with MS in 2021, was hospitalized in Los Angeles late last month. However, it was unclear if the reason had anything to do with her autoimmune disease.

“I have no comment on whether she is in the hospital or what her medical treatments are,” a rep for the actress told Page Six in a statement at the time. “She’s had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast.”

Applegate later gave an update on her health via Instagram, telling her followers that she’s feeling “better every day.”

“Thank you for the outpouring of love and well wishes. Health issues are a constant for me, but I’m a strong chick and I’m getting stronger and better every day.”

“I’m taking a moment to focus on my health, but I’ll be back with more to say soon enough.”