Add Trent Grisham to the list of Yankees injury concerns.

Grisham left Wednesday’s 2-1 loss to the Blue Jays with left knee discomfort, the Yankees announced, and the center fielder will undergo imaging Thursday.

Grisham suffered the injury on a double in the bottom of the second, when his pop-up down the left field line dropped in.

He remained in the game through the top of the fourth.

“I felt something weird in my knee,’’ Grisham said. “It didn’t feel like something I should mess with, so I got out of the game.

Though Aaron Boone said the fact Grisham had to come out was worrisome, Grisham said he was “very optimistic” the injury isn’t serious.

Grisham was replaced by Spencer Jones in center in the top of the fifth before Cody Bellinger moved there when Amed Rosario hit for Jones in the seventh, with Rosario in left.

The lefty-swinging Jones, who went 0-for-1, entered Wednesday just 3-for-20 with three walks, 11 strikeouts and no extra-base hits since being recalled from Triple-A Scranton/Wilkes-Barre to replace Jasson Domínguez, who’s on the injured list with a sprained left shoulder.

Domínguez suffered that injury crashing into the left field fence at Yankee Stadium on May 7.

He started swinging off a tee Wednesday and there’s no timeline for his return.

Domínguez said before Wednesday’s game the sprained AC joint is “still a little uncomfortable.”

He’s played in nine games with the Yankees this season after opening the year with SWB.

Grisham, coming off a breakout season in which he hit 34 homers a year ago, has mostly struggled at the plate this season, with a .639 OPS.

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With José Caballero expected to return from the IL when he’s eligible on Friday after being out with a fractured middle finger, Anthony Volpe’s future at the position remains murky.

After a rough start upon his call-up from Triple-A Scranton/Wilkes-Barre — which included an error on a routine grounder and a pair of strikeouts in four hitless plate appearances — Volpe entered Wednesday having reached base 12 of his previous 20 plate appearances (five hits and seven walks) with just two strikeouts.

He went hitless Wednesday.

And Volpe played a steady shortstop, something he didn’t do last year, playing much of the season with a labrum injury in his left shoulder.

“I think he’s looked outstanding,’’ Boone said before Wednesday’s loss.

The manager praised Volpe’s at-bat quality, hard contact, defense and called his baserunning “excellent.”

“It’s a credit to him and just his physical and mental toughness that he dealt with a tough little situation to start the year,’’ Boone said. “[He’s] kind of showing you who he is and what he’s made of.”

But Boone declined to say that Volpe — or Caballero — would be the Yankees’ starting shortstop when Caballero returns.

“We’ll see,’’ Boone said of the position when asked about it more than once.

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Yovanny Cruz made his MLB debut and tossed two scoreless innings against the Blue Jays.

The hard-throwing right-hander never pitched above Double-A before this season, but impressed the Yankees with his triple-digit stuff during spring training and it was on display Wednesday.

Cruz retired all six batters he faced and 13 of his pitches were strikes.

His command and ability to keep runners from stealing bases were among the issues Cruz had in the minors and he got off to a promising start in The Bronx.

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Matt Blake knows what the numbers say about David Bednar, but the pitching coach isn’t down on the closer.

“Typically he’s cleaner than what he’s been, but the numbers are better than his [5.14] ERA indicate,’’ Blake said.

Bednar has had issues with his fastball command, but he’s also allowed two homers on his curveball — including the three-run shot to Tyrone Taylor that turned the tide of the Subway Series.

As Blake noted, that has been an effective pitch for Bednar. The pair of homers against Bednar’s curve are as many as he allowed since 2022.

But there’s also the issue of Bednar allowing a ton of hits so far this season, even if some have been on soft contact.

And in his 21 appearances, Bednar has allowed the leadoff hitter to reach 10 times.

“There’s been more runs and traffic than we’d like,’’ Blake said. “But I fully believe he’ll work his way through it.”