Ten people were hurt — including seven police officers — when a home exploded and burned down while cops were responding to a dispute involving a knife, according to police and fire officials.

Police responded to a reported dispute at a home on 130th Street in South Ozone Park around 2:42 a.m. Thursday — but when officers tried to get into the residence there was an “explosion,” NYPD said.

The blast sparked a massive, five-alarm inferno that quickly spread throughout the two-and-a-half-story private home and extended to a house next door.

Photos from the scene show that the building collapsed and was completely destroyed.

Ten people were rushed to local hospitals with minor injuries — seven of them police officers, according to NYPD and FDNY.

Rattled neighbor Jessica Irving said she heard “what sounded like gunfire” amid the chaos after the initial blast — although officials have made no suggestion there was a shooting.

Irving recalled hearing a “blood-curdling scream” as police ordered her to evacuate her house. She fled down the street in her car, she said.

“It was just a lot of commotion of yelling,” she told FreedomNewsTV.

It was not immediately clear what the dispute — which sources told The Post involved a knife — was about.

No arrests have been made and the cause of fire remains under investigation.