Dave Coulier revealed his shocking 45-pound weight loss transformation due to his brutal cancer treatments.

“I haven’t posted in quite a while, and the last time I did some of you said that I look differently and I sound differently, and I do,” said Coulier, 66, in his Thursday Instagram Reel.

“What you’re seeing is the side effects of extensive radiation that I went through carcinoma in my throat.”

“I haven’t been able to eat solid food in months, and so I’ve lost 45 pounds. That’s what you’re seeing, and it’s affected my ability to speak,” he explained.

“Some of you said that I sound differently. So yeah, you’re right on with what you are seeing and what you hearing.”

“But just to recap, a year and a half ago I had non-Hodgkin’s lymphoma and I went through chemotherapy, and my hair is kind of growing back. And we got our PET scans back, and the prognosis looks good for both the carcinoma in my throat and the lymphoma. So we’re very pleased with all of that,” he added.

The “Full House” alum revealed he was diagnosed with stage 3 non-Hodgkin lymphoma in 2024. By the following March, he revealed he was cancer-free.

However, he went on to share that he was diagnosed with HPV-related oropharyngeal tongue cancer just nine months later.

In February, he announced that he was in remission from both cancers after a two-year battle.

But, despite his “good news,” Coulier admitted he feels “like cancer is always in the rearview mirror behind” him.

In April, Coulier opened up about how his “toxic” lifestyle led to his cancer diagnosis during an appearance on “The Kelly Clarkson Show.”

“I wanted to know, ‘Why did my lymphatic system crash?’ And I realized as I went down the rabbit hole, everything in my life was toxic,” Coulier admitted. “My toothpaste, my shampoo, the garbage bags, the toilet paper, everything, skin cream, everything.”

“I said, ‘I need to change this, but how do I do it?’ It’s a pretty daunting task to change your lifestyle like that. So I changed one thing. I replaced my toothpaste. And I thought, ‘I put that in my mouth every day, I’m gonna start there,'” he shared.