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2026 NFL Draft Day 2 odds: Who 49ers, Cardinals, Bills ar...
Erich Richte · 2026-04-25 · via New York Post
Chase Bisontis is projected by oddsmakers to hear his name early in Round 2.
Chase Bisontis is projected by oddsmakers to hear his name early in Round 2. AP

The first round has come and gone, and it’s time to look at the NFL Draft Day 2 odds as we move into Friday.

Some elite talent remains available, as the 49ers are on the clock at No. 33 overall, the first pick of the second round, assuming no trades.

The best players available, according to ESPN’s Mel Kiper Jr., include cornerback Jermod McCoy, safety Emmanuel McNeil-Warren and wide receiver Denzel Boston, at the top three slots.

We’ve already seen some substantial odds movement early in the day Friday ahead of Round 2.

Texas A&M standout offensive lineman Chase Bisontis from Don Bosco Prep in Ramsey, N.J. opened as the betting favorite to be selected with this pick (+430, FanDuel) but has fallen to +500 odds, putting him behind Boston (+380, FanDuel).

Bisontis is a lukewarm +700 favorite to go No. 34 overall to the Cardinals, but that price suggests that it’s anyone’s guess who is getting picked at this time.

Here are the betting odds for Day 2 of the NFL Draft.

Denzel Boston of the Washington Huskies runs with a football during the 2026 NFL Scouting Combine.
Denzel Boston is viewed likely to land with the 49ers or Bills, according to oddsmakers. Getty Images

NFL Draft Day 2 betting odds

PickBetting odds
No. 33 (49ers)1. Denzel Boston, WR (+380)
2. Emmanuel McNeil-Warren, S (+450)
3. Chase Bisontis, OL (+500)
4. T.J. Parker, EDGE (+600)
5. Zion Young, EDGE (12/1)
6. Emmanuel Pregnon, OL (15/1)
7. Jermod McCoy, CB (16/1)
8. Colton Hood, CB (18/1)
9. Kayden McDonald, DT (18/1)
10. Cashius Howell EDGE (18/1)
No. 34 (Cardinals)1. Chase Bisontis, OL (+700)
2. T.J. Parker, EDGE (+800)
3. Denzel Boston, WR (+800)
4. Kayden McDonald, DT (+800)
5. Cashius Howell, EDGE (+950)
6. Colton Hood, CB (+950)
7. Zion Young, EDGE (11/1)
8. Carson Beck, QB (12/1)
9. Jermod McCoy, CB (12/1)
10. Garrett Nussmeier, QB (16/1)
No. 35 (Bills)1. Denzel Boston, WR (+500)
2. Kayden McDonald (+600)
3. Jacob Rodriguez, OL (+950)
4. Colton Hood, CB (+10/1)
5. Emmanuel Pregnon (13/1)
6. Emmanuel McNeil-Warren, S (13/1)
7. Zion Young, EDGE (13/1)
8. T.J. Parker, EDGE (13/1)
9. Cashius Howell, EDGE (13/1)
10. Christen Miller, DT (15/1)

The second round opens with the 49ers, Cardinals, Bills, Raiders and Giants in that order, while the Jets will be back on the block with the No. 44 pick.

Why Trust New York Post Betting

Erich Richter is a brazilian jiu-jitsu blue belt but he has a black belt in MMA betting. During the football season he’s showcased massive profits at The Post in the player prop market the last two seasons. While constantly betting long shots, his return on investment is 30.15 percent since 2022.