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Christina Applegate's former co-star gives rare update on actress' 'very hard' MS battle after hospitalization
Eric Todisco · 2026-06-12 · via New York Post

David Faustino, who played Christina Applegate’s brother in “Married… With Children,” revealed the actress still has her signature humor as she battles multiple sclerosis.

“It’s been very hard for her, but she does keep her humor,” Faustino said in a new interview with US Weekly, calling Applegate’s MS diagnosis “a real blow.”

Faustino, 52, said Applegate, 54, has had a “dry, sarcastic sense of humor since the moment I met her,” and despite the serious health battle that left her recently hospitalized, “nothing has changed.”

David Faustino and Christina Applegate at the 7th Annual TV Land Awards in 2009

David Faustino gave an update on “Married… With Children” co-star Christina Applegate as she battles MS (Faustino and Applegate are pictured above at the 2009 TV Land Awards). FilmMagic

David Faustino and Christina Applegate at the "Vacation" premiere in 2015

Faustino said Applegate (both seen above at the “Vacation” premiere in 2015) still has a “dry, sarcastic sense of humor” despite her health battle. Getty Images

The “Dead to Me” star is still “extremely sarcastic” and “extremely dry,” Faustino confirmed.

“She gets through this with some humor, and that’s kind of her way that she moves through it,” the voice actor explained, noting he’s been “a support” to Applegate since she announced her diagnosis in June 2021.

Faustino also confirmed he’s in regular contact with the Emmy Award winner.

“I do a lot of visits with her. A lot of texting, a lot of checking in,” he said. “A lot of funny just crap that we talk about. And that’s all I can do, right? Give her my love.”

David Faustino, Christina Applegate in "Married... With Children"

Faustino said “nothing has changed” about Applegate (The actors are pictured above in “Married… With Children”). ©20thCentFox/Courtesy Everett Collection

David Faustino and Christina Applegate in 1989

Faustino confirmed he regularly sees and talks to Applegate (Both are pictured above in 1989). Ron Galella Collection via Getty Images

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He added, “We do have deep convos when we sit. But we also keep the laughter [going] as well.”

Applegate and Faustino played siblings Kelly and Bud Bundy, respectively, in “Married… With Children.”

The sitcom, which aired on Fox from 1987 to 1997, also starred Ed O’Neill and Katey Sagal as their parents, Al and Peggy Bundy.

Christina Applegate, David Faustino in "Married... With Children"

Faustino (seen above with Applegate in their Fox sitcom) said they’ve had “deep convos” lately. ©20thCentFox/Courtesy Everett Collection

Ed O'Neill, David Faustino, Christina Applegate in "Married... With Children"

Applegate (pictured above with Faustino and Ed O’Neill in “Married … With Children”) announced her MS diagnosis in 2021. ©20thCentFox/Courtesy Everett Collection

Applegate gave an update on her health in April after she was hospitalized in Los Angeles.

“Thank you for the outpouring of love and well wishes. Health issues are a constant for me, but I’m a strong chick and I’m getting stronger and better every day,” she wrote on Instagram.

“I’m taking a moment to focus on my health, but I’ll be back with more to say soon enough,” the “You With the Sad Eyes” author added.

Applegate’s rep wouldn’t confirm if the actress was hospitalized due to her autoimmune disease.

“I have no comment on whether she is in the hospital or what her medical treatments are,” the rep told Page Six in a statement on April 16. “She’s had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast.”

Christina Applegate, David Faustino and Katey Sagal

Applegate, who is pictured above with Faustino and Katey Sagal at her Hollywood Walk of Fame star ceremony in 2022, was hospitalized earlier this year, though her rep wouldn’t say if it was because of her MS. AFP via Getty Images

Christina Applegate

Applegate (pictured above at the 2023 Critics Choice Awards) told fans in April she’s “getting stronger and better every day.” Getty Images for Critics Choice Association

In February, Applegate revealed she’s been confined to her bed due to ongoing pain, but she still tries to take her 15-year-old daughter, Sadie, to school.

“I want to take her; it’s my favorite thing to do. It’s the only time we have together by ourselves,” the “Friends” star explained.

“I tell myself, ‘Just get her there safely and get home so you can get back into bed.’ And that’s what I do,'” she added.