The final matchup from Major League Baseball this weekend is the series finale of the NL Central rivalry between the Chicago Cubs and the St. Louis Cardinals. The two teams split the first two games in the series and come in separated by just a half-game in the division. Whoever wins this matchup will be sitting second behind the Brewers heading into June. Let’s take a look at my top three best bets from the player prop market in this Sunday Night Baseball matchup.

The Cardinals are slight home favorites at -118 on the Moneyline, but the Cubs are getting 51% of the bets as of Sunday afternoon. The over/under is 8.5 runs, with 69% of bets coming in on the over.

For each Major League Baseball matchup, DraftKings Sportsbook has a wide variety of batter and pitcher props on the board, so let’s take a look at a few strong plays for Sunday night.

Cubs at Cardinals Prop Bets for 5/31/26

Ivan Herrera 3+ Hits + Walks + Earned Runs Allowed (+155)

The Cubs will start hittable lefty Jordan Wicks (more below), which sets up well for a big game from Herrera, who I also included in my home run props for this afternoon and evening. The right-handed hitter has split time this year between catcher and designated hitter, hitting second in the order in each of his 56 games. Overall, he’s hitting .260 with seven homers, 33 runs and 27 RBI. He has collected 114 HRR (hits, runs and RBI) for an average of 2.0 HRR per contest.

Herrera has been making much better contact lately, with a 39.3% hard-hit rate and 14.3% barrel rate over his last 10 games. He has averaged 2.4 HRR per game over that 10-game span, and he had 4 HRR on Friday in the win over the Cubs before coming up empty by going 0-for-4 on Saturday.

Facing the lefty Wicks puts him on the strong side of his splits, and he has hit five of his seven homers in his 28 games at at home. If the Cardinals are able to pile up runs against Wicks, Herrera should be right in the middle of the action and find a way to get to 3+ HRR. He can get there with a home run or with multiple hits, runs or RBI.

Jordan Wicks Over 2.5 Earned Runs Allowed (+105)

Wicks has made one start this season in the majors, giving up eight runs in 4 1/3 innings against the Pirates. He made seven starts in Triple-A, posting a 4.44 ERA and allowing 13 runs in 26 1/3 innings, including back-to-back games with six runs against him.

In 2025, he allowed 10 earned runs in 14 1/3 innings in the majors, and in the minors, he had a 3.55 ERA in 20 games in Triple-A. This year, things have gone even worse in the minors, and opponents have a 10.7% barrel rate against him, which could spell trouble against he Cardinals scrappy, hard-hitting righties.

Wicks has had a few strong outings over the years, including in September of last year when he spun three shutout innings against the Cardinals out of the bullpen towards the end of the season. His last start against the Pirates, though, wasn’t encouraging, and the Cardinals lineup has been solid enough this season to put three earned runs or more on him this Sunday night.

Matthew Liberatore Over 4.5 Strikeouts (-121)

On the other side of the pitching matchup, the Cardinals will go with Matthew Liberatore. Liberatore is 2-3 in his 11 starts this season with a 4.76 ERA, 4.65 FIP, and 53 strikeouts in 56 2/3 innings. He has a solid 21.4% K%, which would be the highest strikeout rate of his career, and he has gone over this prop line in four straight starts.

Liberatore had a season-high 10 strikeouts in his most recent outing, which was last Monday on the road in Milwaukee. He had nine punchouts against Pittsburgh in the start before that as well, and he’s building some nice momentum as one of the team’s promising young arms.

Liberatore is actually a year younger than Wicks, even though he has much more experience in the majors. He hasn’t faced the Cubs this year, but he had two starts against them last year, striking out nine in a total of 12 innings.

With his good strikeout form, Liberatore has a good chance to get to this attainable strikeout total on Sunday night.

JJ Wetherholt 2+ Total Bases (+123)

Let’s wrap up our Sunday night player prop bets with another bat from the Cardinals. Rookie JJ Wetherholt is a left-handed hitter, but even in a lefty-lefty matchup, he’s a strong play to get multiple total bases.

He picked up three singles on Saturday and has hit safely in eight of his last 10 games. He’s hitting .293 with a .345 wOBA over that span, and he has picked up multiple total bases in each of his last three games and five of those 10 contests.

For the season, he has 86 total bases in 55 games, for 1.6 total bases per game.

If you’re looking to be more aggressive with your Sunday Night Baseball prop bets, you can combine the four prop bets in this post into a nice +1000 SGP (Same Game Parlay) as you can see below.