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MLB Best Bets Today: Baseball Picks, Predictions for Saturday 4/25/26
Bryan Armett · 2026-04-26 · via DraftKings Network

Bryan Armetta breaks down his three favorite MLB bets today on DraftKings Sportsbook for Saturday’s 15-game slate.

15 games between 30 teams make up today’s slate of MLB games. There are several outstanding matchups on tap, starting this afternoon with the AL Central-leading Guardians visiting Toronto, the defending AL champions. Later, the Yankees will attempt to earn a series win vs. the rival Astros. As a nightcap, the Cubs hope to extend their winning streak to 11 games against the juggernaut Dodgers.

With so many contests on deck, the options are endless for bettors. Before the start of Saturday’s action, here are three MLB bets worth placing on DraftKings Sportsbook.


Padres vs. Diamondbacks under 16 runs (-108)

No, do not refresh your browser. Tonight’s total for this NL West showdown is set at 16 runs. What seems like an outlandish number on first glance isn’t too far fetched. After all, the Diamondbacks have hit the over in eight of their 13 games this season at home. Their pitching is also surrendering 5.62 runs per game at Chase Field, fourth-most in baseball. At the dish, Arizona’s .417 slugging percentage is good enough for sixth-best in baseball. That’s bad news for the visiting Padres, who are sending German Marquez to the mound. The former All-Star’s 3.86 ERA is misleading; his 5.97 FIP suggests negative regression is imminent. In addition, his 2.4 HR/9 ratio isn’t ideal against anyone, let alone a top-ten lineup.

With all that being said, much of the reason I’m backing the under tonight is due to Zac Gallen. The right-hander, following a terrible 2025 campaign, has looked more like himself this season. Through 25.2 innings of work, the former All-Star has posted a 3.51 ERA, in spite of his 1.48 WHIP. He’s also been terrific through two outings at home (1.54 ERA). Gallen also owns a stellar 2.50 ERA during his last six appearances vs. San Diego. The Padres are only scoring 3.92 runs per game on the road, eighth-worst in the league. Could both arms deliver lackluster performances tonight? Sure, but an absolute slugfest feels like a bit of a reach. All bettors need for the under to hit is one of Marquez or Gallen to keep things in check.

Rangers under 3.5 total runs (+105)

Globe Life Field has proven to be a pitcher’s paradise. Last season, it was tied for the American League’s second-worst run scoring environment, per Savant. That’s a welcome sight for this Athletics rotation, which spends half of their games at hitter-friendly Sutter Health Park. On Friday, struggling starter Luis Severino tossed a 6.2-inning, one-run gem in Arlington. Tonight, Jeffrey Springs will attempt to do something similar. Through 29.2 innings this season, the ninth-year pro has notched a stellar 3.34 ERA, 0.98 WHIP and 27 strikeouts.

It’s not just that Springs is dealing at the moment. The Rangers have gone cold at the dish when playing at Globe Life. Their 2.80 runs per game at home rank as the second-lowest mark in all of baseball. Facing a tough southpaw doesn’t look like a recipe for success. Texas has a .583 OPS against left-handed pitching, third-worst in the majors. The team has scored three runs or less in seven of their ten games at home this season. Springs owns a 2.51 ERA during his last five meetings with the Rangers. Add it all up, and Texas is poised for another low-scoring matchup.

Reds ML (-108)

In this interleague showdown, it’ll be Brady Singer on the mound for Cincinnati. It’s been a difficult first month for the right-hander. Through 23.2 innings, he’s posted a mediocre 5.32 ERA, 1.65 WHIP and 16 strikeouts. Per Savant, he’s inside the bottom fourth percentile in pitching run value (-7). With that being said, three of Singer’s five starts this season have been on the road. Since 2025, he owns a terrific 3.32 ERA when pitching in Cincinnati. In comparison, Detroit is averaging baseball’s tenth-fewest runs during away games (4.0).

It’s a similar story for Tigers hurler Jack Flaherty, who tends to operate better at home. In away games, the former All-Star has posted a mediocre 4.74 ERA over the past two seasons. To make matters worse, Flaherty owns a 18.0% base on ball ratio in 2026, among baseball’s bottom 3% of pitchers. On the flip side, Cincinnati ranks seventh in the league with 4.23 walks per game. A once-struggling Reds lineup has shown signs of life recently. They’ve scored at least five runs in five of their last six outings. That bodes well for Cincy’s chances at winning on Saturday.