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DraftKings MLB Pick6 Fantasy Baseball Picks: Top Plays for Thursday 5/21/26
Blake Krass · 2026-05-21 · via DraftKings Network

Blake Krass shares his top fantasy baseball Pick6 picks and plays for the Thursday slate. Check ’em out here!

The MLB season is rolling along. There are far more ways to get involved in the action than just via traditional betting. One of the more unique features on DraftKings this year is Pick6 Fantasy Baseball!

Here are my top Pick6 plays for today’s MLB slate.


DraftKings MLB Pick6 Plays

Shea Langeliers More Than 1.5 Total Bases

Shea Langeliers has been one of the best hitters in baseball this season. His .972 OPS is the fourth-best mark in baseball in 2026. He should keep his great season going against Jose Soriano and the Angels. Soriano has given up five or more runs in two of his past three games. The Angels also have the second-worst bullpen ERA in baseball, at 5.60. Langeliers has dominated Soriano over the years. He has a 1.765 OPS in his career against Soriano. In six career at-bats against Soriano, Langeliers has three extra-base hits, including two home runs. Langeliers should hit Soriano hard in this game and record another extra-base hit.


Juan Soto More Than 0.5 Runs + RBIs

Juan Soto has returned to Washington to face his former team for a four-game series. While the Mets are struggling to win ballgames, Soto is crushing his old team at the plate. In the three games of this series so far, Soto has three home runs, six RBIs, five runs scored and six total hits. Over the last 15 days, Soto has a 1.038 OPS. He has combined for 24 runs + RBIs over that stretch. Soto should stay hot in this series finale against the Nationals. Cade Cavalli is on the mound for Washington, and he has a 4.05 ERA this season. Cavalli has really struggled against left-handed hitters this season. He is allowing a .356 batting average and a .916 OPS to opposing lefties this season. Even once Cavalli exits the game, the Nationals have a 4.95 bullpen ERA, the fifth-worst mark in the league. Soto should have one more big game against his former team in Washington.


Ronald Acuna Jr. More Than 0.5 Runs

Ronald Acuna Jr. returned from a short injury for this series in Miami. He missed just over two weeks of action at the start of this month, but has been in the lineup each of the last two games. So far in this series against the Marlins, Acuna has two hits and four runs scored across two games. Acuna has not crushed at the plate this season the way he has in the past. However, he has been able to get on base. That is really all that’s been needed with how amazing the Braves’ lineup has been this season. Acuna batting leadoff with the likes of Matt Olson, Michael Harris II and Ozzie Albies coming up behind him, he has managed to score a lot of runs. He should keep scoring runs against the Marlins in this game against Sandy Alcantara. Acuna has a 1.026 career OPS against Alcantara. Acuna should get on base in this game and get driven in by his teammates.


What is DraftKings Pick6?

Pick6 is a peer-to-peer fantasy variant where you build a lineup (your “Pick Set”) of 2+ players and select whether or not you believe each will outperform their listed stat projection. Enter your Pick Set in Pick6 contests to compete against other users. Get enough picks correct and win a share of cash prizes.

How to Play

Create a Pick Set

Create a Pick Set by choosing 2+ players from the same sport and Pick Group (a set of picks available from a group of competitions). For each player, simply select if you think they’ll have more or less than their listed stat projection. In each Pick Set, you can not pick the same player twice, and you must pick players from at least two different teams.

Enter an Amount

Once you finalize your Pick Set, choose your entry fee amount. Your entries will be automatically distributed into available contests, subject to your confirmation.

Sweat Your Picks

When the games go live, use the My Picks tab to follow your picks in real time to track how your players are performing against their projections and how they stack up against other users.

Compete for Prizes

Make enough correct picks and win a share of the contests’ guaranteed prizes. Any prizes won will be credited to your DraftKings account after contests are finalized.


Play at DraftKings Pick6 or by downloading the DraftKings Pick6 app on Apple or Google!


Gambling Problem? Call 1-800-GAMBLER. Must be at least 18 years or older. Higher age limits may apply in some states. Eligibility restrictions apply. Valid only in states where DraftKings Pick6 operates. Void where prohibited. For entertainment purposes only. Winning a contest on DraftKings depends on knowledge and exercise of skill. See terms at pick6.draftkings.com.