Two straight wins have given the Yankees () a boost in their quest to win the AL East. Last season’s division champs, the Blue Jays (), have struggled mightily in 2026. Toronto will attempt to turn things around tonight with rookie Trey Yesavage on the mound. Can New York earn a series win on Wednesday?

The Yankees are favorites (-175) over the Blue Jays, with the over/under set at 7.5 runs. Below, I’ve laid out my preview, prediction, and best bet for Wednesday’s showdown between Toronto and New York on DraftKings Sportsbook.

Blue Jays vs. Yankees prediction, preview

Tonight’s pitching matchup offers a glimpse at the AL East’s future. After starting off on the injured list, Yesavage will make his fifth start of the season on Wednesday. Through 19.1 innings of work, the right-hander has notched a 1.40 ERA, 1.29 WHIP and 21 strikeouts (9.8 K/9). While operating on a modest workload, the 22-year-old hasn’t allowed more than two earned runs in any of his appearances. It’s also worth noting that he’s had some notable success in this spot before. Yesavage befuddled the Yankees last postseason, striking out 11 batters over 5.1 hitless innings.

A repeat performance of that magnitude will be difficult to come by, especially on the road. New York is averaging an MLB-best 6.50 runs per game at home. That’s nearly a whole run better than Washington, the next-closest team in that category. On paper, a relatively unproven hurler taking on a lefty-laden lineup could signal trouble for the visitors. Including 14.1 innings last season, Yesavage owns a career 4.1 BB/9 ratio. It’s a small sample size, but worth mentioning in this matchup. The Yankees have earned an American League-best 4.61 walks per game. Navigating the dangerous bats of Ben Rice (191 wRC+) and Aaron Judge (168 wRC+) could prove to be the difference for Toronto.

On the other side, it’ll be none other than Cam Schlittler toeing the slab for New York. If the season ended today, it’d be difficult not to pencil in the righty as a Cy Young winner. Over ten appearances, he’s pacing the AL in ERA (1.35) and WHIP (0.78), in addition to a 10.2 K/9 ratio. The righty has allowed one earned run or fewer in eight of his starts so far. That level of dominance is no fluke, either. Schlittler ranks within the top percentile in pitching run value, per Savant. He’s on the hook for a mediocre 5.64 ERA over three games against Toronto. However, those contests took place in 2025; it’s clear that Schlittler has improved in a major way this season.

It’s not as if the Blue Jays are the most formidable opponents at the plate right now. This group owns a .305 xwOBA, second-lowest in the majors. Although Toronto does a good job of avoiding strikeouts, there isn’t much star power in this lineup outside of Vladimir Guerrero Jr. Injuries to Alejandro Kirk (thumb) and Addison Barger (elbow) certainly haven’t helped. Only two members of Toronto’s active roster, Guerrero and Daulton Varsho, have notched a wRC+ above 110. The defending American League champs have combined for a .677 OPS, fifth-worst in all of baseball.

Blue Jays vs. Yankees pick, best bet

Yankee fans would be forgiven for having bad flashbacks to last October against Yesavage. While Toronto’s top prospect is legit, it doesn’t look like he’ll garner a ton of run support in this one. Despite some success last year against Schlittler, the Blue Jays are sending a much different lineup to the field tonight. Expect New York’s ace to take care of business and clinch a series win on Wednesday.

Best Bet: Yankees -1.5 (+123)