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Opening odds and spread for Bills vs Texans in NFL Week 1
Ciaran Doyle · 2026-05-15 · via DraftKings Network

Ciaran Doyle gives his best bet on DraftKings Sportsbook for the Bills vs. Texans Week 1 matchup.

Published May 14, 2026 8:50 PM EDT

DENVER, CO - JANUARY 17: Josh Allen #17 of the Buffalo Bills runs out of the tunnel prior to an NFL divisional playoff football game against the Buffalo Bills at Empower Field At Mile High on January 17, 2026 in Denver, Colorado. (Photo by Cooper Neill/Getty Images)

DENVER, CO - JANUARY 17: Josh Allen #17 of the Buffalo Bills runs out of the tunnel prior to an NFL divisional playoff football game against the Buffalo Bills at Empower Field At Mile High on January 17, 2026 in Denver, Colorado. (Photo by Cooper Neill/Getty Images)

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The opening odds for the Buffalo Bills vs. Houston Texans Week 1 matchup on Sunday are now available on DraftKings Sportsbook.

Bills vs. Texans Opening Odds

The Bills open as 1.5-point favorites for this game. They are slight -112 favorites on the moneyline, while the Texans are -108 on the moneyline. The O/U is listed at 45.5 points.

These teams met up in Week 12 last season, with the Texans defense dominating in a 23-19 win. Can Houston get another home win over Buffalo in Week 1 of the new season?

This AFC matchup is one of the better ones on Sunday’s slate. Two playoff teams from a year ago will battle it out for the right to start the season 1-0.

Ciaran has been an editor for the DraftKings Network team since 2023. He graduated from the University of Arizona before attending Arizona State University for his master’s degree in sports journalism. Ciaran previously covered Phoenix Rising FC for Cronkite News before joining DraftKings. He is passionate about sports betting, and his biggest focus has always been on the NFL and soccer. You can find him on X at @Ciaran_Doyle7.

I am a promoter at DraftKings and am also an avid fan and user (my username is ciarandoyle77) and may sometimes play on my personal account in the games that I offer advice on. Although I have expressed my personal view on the games and strategies above, they do not necessarily reflect the view(s) of DraftKings and do not constitute a representation that any particular strategy will guarantee success. All customers should use their own skills and judgment in building lineups. I may also deploy different players and strategies than what I recommend above. I am not an employee of DraftKings and do not have access to any non-public information.

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