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Boston Red Sox vs. New York Yankees prediction, pick for MLB on Wednesday 4/22/26
Dan Johnson · 2026-04-23 · via DraftKings Network

Dan Johnson takes you through his preview, prediction, and best bet for today’s baseball game between the Boston Red Sox and the New York Yankees.

New York walks into Fenway at 14-9 with control of the division and a clean 4-0 win already pocketed in this series, while Boston sits 9-14 and still searching for traction. This isn’t a warm, chaotic Fenway night where the ball jumps and turns everything into a track meet. Mid-40s air, a 7.5 total, and two left-handers set the tone for something tighter. Against this sorry Red Sox roster, the Yankees don’t need a big night. They just need the first crack. Below is my preview, prediction, and pick for today’s baseball game between the Boston Red Sox and the New York Yankees.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Red Sox vs. Yankees prediction, preview

TMax Fried is built for that window. Through the first pass, hitters are managing just a .236 wOBA and .150 average against him in 11.2 innings, with 13 strikeouts, only four walks, a 3.09 ERA, and a .244 OBP allowed. The second pass hasn’t opened anything up either—just a .141 wOBA, .116 average, .156 OBP, and 0.71 ERA across 12.2 innings, with only five hits, one earned run, and six strikeouts. That’s a starter controlling innings, not surviving them. Ranger Suárez is the opposite kind of puzzle. The first look is clean—0.93 ERA, .286 wOBA, .273 average, and only one earned run in 9.2 innings—but once the lineup turns, it shifts hard: 7.56 ERA, .343 wOBA, .471 slugging allowed, seven earned runs, and two home runs in 8.1 innings the second time through. That’s where this bet lives. Not in an immediate ambush, but in that second cycle where the Yankees get their best swings.

And this lineup has enough to capitalize even if the batting average doesn’t impress. The Yankees are hitting just .191/.293/.396 against lefties, but the power hasn’t disappeared—13 home runs in 17 games in that split, then 11 more over their last 10 against left-handed pitching with a .430 slugging percentage, 25 RBI, and 25 walks. Aaron Judge is still the gravity center with a .235/.343/.588 season line and nine home runs, while Ben Rice has been a problem all month at .319/.461/.754 with eight home runs and 18 RBI. Cody Bellinger is sitting at .278/.385/.456, and his lefty split has stayed playable, while Giancarlo Stanton broke the opener open with a solo homer and a two-run double, driving in three of New York’s four runs. Randal Grichuk added two hits in that game, and New York finished with 10 hits total. This is not a contact offense—it’s a mistake-punishing one, built on walks and extra-base damage more than batting average.

Boston’s path is thinner. The Red Sox are hitting .223/.298/.332 against left-handed pitching with just three home runs in 20 games, which is a weak power profile for a team facing Fried at Fenway in a low-total game. Their recent shape against lefties has been just as flat: over their last five in that split, they were hitting .200 with a .263 OBP, .286 slugging percentage, one home run, and 23 strikeouts in 70 at-bats. There are individual bats that can bite—Wilyer Abreu has been one of Boston’s more stable producers overall, and Masataka Yoshida has been one of the cleaner average bats in the split—but this isn’t a lineup consistently creating lift or sustained pressure against left-handed starters. And when you pair that with Fried’s ability to choke off the first two trips, the scoring window for Boston gets squeezed into something very specific and much less likely.

Yankees vs. Red Sox pick, best bet

Suárez has been hot—14 scoreless innings across his last two starts, dropping his ERA from 8.64 to 3.22—and Fenway always leaves room for one crooked inning. If the Yankees don’t convert that second pass, this can absolutely sit at 0-0 or 1-1 longer than you want. But that’s also why this is priced where it is. You’re not paying for certainty—you’re getting plus money on a very specific edge.

And that edge is early separation, not full-game control. Yankees ML drags you into nine innings and Boston’s chaos lanes. F5 ML burns you on a tie. F5 -0.5 at +105 is the only number that actually aligns with how this game is most likely to break: Fried suppresses, Suárez bends the second time through, and New York lands the first real punch. Team-level context supports that shape too: the Yankees are averaging 0.83 first-inning runs per game, one of the best marks in baseball, while Boston’s offense against lefties has been one of the flatter power groups in the league.

Yankees F5 -0.5 (+105). The way it dies is simple—Suárez holds that second turn and Fried gives up one swing—but everything underneath still points the same direction.

Yankees 3, Red Sox 1 through five.

Best bet: Yankees F5 -0.5 (+105) at Red Sox

Tail it with me in the DKN Betting Group here!