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San Francisco Giants vs. Arizona Diamondbacks prediction, pick for MLB on Monday 5/25/26
Dan Johnson · 2026-05-26 · via DraftKings Network

Dan Johnson takes you through his preview, prediction, and best bet for today’s baseball game between the San Francisco Giants and the Arizona Diamondbacks.

Arizona arrives in San Francisco with the kind of momentum that makes a sub-.500 home team feel less comfortable than the line suggests. The Diamondbacks are 28-24, third in the NL West, and just finished a 6-1 homestand with a 9-1 thumping of Colorado that included 13 hits, seven extra-base hits, a 7-0 lead by the fourth inning and Ryne Nelson working a career-best eight innings. They also swept the Giants in Phoenix last week, including a 5-3 walk-off win after San Francisco carried a 3-1 lead into the ninth. The Giants are still only 22-31, but the weekend finally gave them something louder than patience: 18 runs across two wins over the White Sox, 10 on Saturday, eight on Sunday, and enough hard contact to make this rematch feel less like a cold team waiting around and more like a lineup that may have found a pulse. Below is my preview, prediction, and pick for today’s baseball game between the San Francisco Giants and the Arizona Diamondbacks.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Giants vs. Diamondbacks prediction, preview

Merrill Kelly is the reason San Francisco’s offense deserves another look. The veteran right-hander enters at 4-3 with a 5.71 ERA, 1.51 WHIP, 41 IP, 44 H, 27 K, 18 BB and eight HR allowed, and the shape underneath those numbers is not much kinder. He owns a 14.9% K rate, 9.9% BB rate, 33.3% ground-ball rate, 5.62 FIP, 4.98 xFIP, 1.76 HR/9, 5.93 K/9 and 3.95 BB/9, which is a dangerous mix for a pitcher facing a team that just rediscovered its power. Landen Roupp gives the Giants the steadier run-prevention side at 5-4 with a 3.27 ERA, 1.15 WHIP, 55 IP, 61 K, 21 BB and only two HR allowed, with a 27.2% K rate, 54.0% ground-ball rate, 2.59 FIP, 3.00 xFIP and 0.33 HR/9. Arizona is the hotter club, but the starting-pitcher contrast gives San Francisco the cleaner foundation.

Kelly’s contact profile turns that foundation into a scoring angle. He has allowed a .371 wOBA, .428 xwOBA, 91.3 mph average exit velocity, 45.6% hard-hit rate, 18.4% barrel rate and 47.8% sweet-spot rate, so the problem is not just traffic; it is the kind of traffic that turns into doubles, homers and crooked innings. Roupp has lived on the other side of the contact map with a .273 wOBA, .269 xwOBA, 86.5 mph average exit velocity, 26.4% hard-hit rate and 2.2% barrel rate, which matters against an Arizona lineup with legitimate top-end bite. Corbin Carroll is riding a 12-game hitting streak after going 4-for-4 with two triples and two RBI on Sunday, while Ketel Marte has an eight-game hitting streak, a recent 10-for-16 surge and the walk-off three-run homer that burned the Giants last week. Tommy Troy also added two doubles in his debut, giving Arizona one more reason to believe this road swing can start fast.

San Francisco’s lineup has been short on length, but the damage pockets are finally doing damage. Casey Schmitt has become the most dangerous current bat in the order with 11 HR, 29 RBI, a .296 average, .556 SLG, .260 ISO, .387 wOBA and 152 wRC+, and he has homered three times in four games. Rafael Devers just drove in five with Sunday’s grand slam, giving him his fifth HR of May, while Luis Arraez brings a .320/.363/.426 contact base and Daniel Susac has opened at .356/.408/.467 in a smaller sample. The injuries to Jung Hoo Lee and Heliot Ramos still matter because they thin out the on-base spine of the offense, but Kelly’s current form gives the Giants’ middle third room to compensate. San Francisco has hit nine HR over the past week and produced three grand slams in eight days, its first such stretch in more than a century.

Diamondbacks vs. Giants pick, best bet

The market leaves more value in San Francisco’s run total than in the side. Giants ML around -130 makes sense because Roupp has the better starter profile, but it asks bettors to pay a short favorite price against the hotter team, the same team that just stole a late game from this bullpen. Giants first five has a case, too, but that route depends on San Francisco leading after exactly five innings against a Carroll-Marte top half that can flip a score quickly. Giants team total over 4.5 runs at +125 is the sharper swing. It attacks Kelly’s 1.51 WHIP, 18 walks, eight HR allowed, 18.4% barrel rate and 45.6% hard-hit rate without needing San Francisco to win the game or separate early. Oracle’s upper-50s/low-60s setting keeps this from becoming a lazy full-game over, but the Giants only need five runs against a starter who keeps giving opponents both baserunners and lift.

Kelly can beat this number if he gets strike one, keeps Schmitt and Devers from batting with traffic and turns the lower third into quick innings before Arizona’s bullpen gets leverage. The stronger read is that San Francisco’s recent power spike and Kelly’s contact trouble meet often enough for one crooked inning and one add-on swing. Best bet: Giants team total over 4.5 runs (+125), playable to +110.

Final score projection: Giants 5, Diamondbacks 3.

Best bet: Giants TT o4.5 runs (+125) vs. Diamondbacks

Tail it with me in the DKN Betting Group here!