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St. Louis Cardinals vs. Arizona Diamondbacks prediction, pick for MLB on Monday 6/22/26
Dan Johnson · 2026-06-23 · via DraftKings Network

Dan Johnson takes you through his preview, prediction, and best bet for today’s baseball game between the New York Mets and the Chicago Cubs.

Arizona opens this road series at 39-38, with its season still balanced between talent and irritation. The Diamondbacks sit 15-21 away from Chase Field, and Sunday’s loss to Minnesota captured the current tension. They drew five walks, produced six hits, went 1-for-8 with runners in scoring position, and left eight men aboard. St. Louis enters 41-34 and 21-17 at Busch Stadium, trying to turn Sunday’s strange 12-10 survival into cleaner traction. The Cardinals finished that game with a season-high 16 hits, three homers, and enough bullpen noise to keep everyone honest. Monday’s matchup creates a sharper lane. Merrill Kelly gives St. Louis a veteran right-hander with diminished miss and elevated damage. Andre Pallante gives the Cardinals a steadier base against an Arizona lineup carrying a harsh right-handed pitching split. Below is my preview, prediction, and pick for today’s baseball game between the New York Mets and the Chicago Cubs.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Cardinals vs. Diamondbacks prediction, preview

Kelly’s season line has moved past mild concern. He brings a 5-6 record, 5.81 ERA, 1.51 WHIP, 28 walks, 15 HR allowed, and 42 strikeouts across 69 2/3 innings. That strikeout total leaves him little room when hitters square him up. The contact indicators look even worse than the surface line. Kelly is allowing 91.3 mph average exit velocity, 45.6% hard contact, a .371 wOBA, .428 xwOBA, and an 18.4% barrel rate. Pallante gives St. Louis the cleaner pitching profile at 8-4 with a 3.76 ERA, 1.20 WHIP, and 62 strikeouts over 76 2/3 innings. He has also gone 5-1 with a 3.20 ERA and 33 strikeouts across his past seven starts. His contact profile sits at 87.7 mph EV, 35.7% hard-hit rate, .296 wOBA, .300 xwOBA, and 6.6% barrels.

The Cardinals’ offensive case starts with a top half capable of making Kelly work immediately. St. Louis owns a .248/.326/.407 slash and .734 OPS against right-handed pitching, and the recent shape has looked stronger. Sunday gave the Cardinals their loudest reminder, with JJ Wetherholt going 3-for-5 with two HR, three runs, and three RBI. Ivan Herrera added a three-run homer and scored three times. Masyn Winn also homered, drove in four, and widened the lineup’s scoring base. The matchup gets stronger if St. Louis keeps Wetherholt, Herrera, Alec Burleson, Walker, Lars Nootbaar, and Winn grouped together. Herrera brings a .401 OBP team lead, while Burleson adds a left-handed damage path with an .826 OPS, 48.3% hard contact, and .387 xwOBA. Nootbaar brings another hammer with premium exit velocity and a double-digit barrel rate.

Arizona’s counter comes from its stars, and that keeps the Cardinals side from becoming too comfortable. Corbin Carroll owns a .281 average, 13 HR, .918 OPS, 49.3% hard-hit rate, and 12.7% barrel rate. Ketel Marte has 12 HR, 46 RBI, and enough switch-hit damage to punish Pallante’s mistakes. Gabriel Moreno enters as the best immediate form bat, with a .357/.438/.571 line across his past seven games. Kelly also carries a 2-1 record and 2.25 ERA in four career appearances against St. Louis, which at least forces some respect. The broader Arizona profile still hurts the upset case. The Diamondbacks have hit .226/.301/.364 with a .665 OPS against right-handed pitching. That split makes them dangerous in clusters, while Pallante’s first-strike style and softer contact profile make full-game Arizona scoring difficult to trust.

Diamondbacks vs. Cardinals pick, best bet

Busch Stadium adds normal baseball weather, not a free offensive boost. Low-70s temperatures and clouds should keep the park fair, while wind pushing in around nine mph trims some cheap carry. That detail matters for the broad markets because both bullpens carry enough damage risk. Arizona’s relief group owns a 4.18 ERA across 269 1/3 innings, while St. Louis sits at 4.39 across 284 2/3 innings. Riley O’Brien has saved games through a 4.18 ERA, and Matt Svanson’s 6.55 ERA gives the late innings volatility. That makes Cardinals -1.5 attractive at plus money, yet exposed after Pallante leaves. The Cardinals team total over 4.5 also fits Kelly’s contact profile. Five runs still demand either early conversion or late bullpen cooperation.

Walker’s 2+ hits + runs + RBI at -134 gives the cleanest expression of the matchup. He leads St. Louis with an .295 average, 18 HR, 58 RBI, and 85 hits, while sitting in the exact run-producing lane this prop needs. The batted-ball profile gives the wager its force: 94.5 mph average exit velocity, 52.1% hard-hit rate, .394 wOBA, .377 xwOBA, and 13.9% barrels. Kelly’s low strikeout rate, 18.4% barrel rate, and 45.6% hard contact create multiple paths. Walker can clear this with a double, one RBI swing, or a hit plus one run behind Herrera and Burleson. The Cardinals should own the better run shape, but the bullpen layer pushes me away from spread exposure.

Best bet: Jordan Walker 2+ HRR (-135), playable to where it’s parked currently.

Projected score: Cardinals 5, Diamondbacks 3.

Best bet: Jordan Walker 2+ HRR (-135)

Tail it with me in the DKN Betting Group here!