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Los Angeles Dodgers at San Francisco Giants prediction, pick for Thursday 4/23/26
Griffin Wong · 2026-04-24 · via DraftKings Network

Griffin Wong gives you a preview, prediction and pick for tonight’s game between the Los Angeles Dodgers and the San Francisco Giants.

For a sports rivalry to be truly great, it needs both volume and even competition, and few rivalries are as intense as that between the Los Angeles Dodgers and the San Francisco Giants. Combined between the regular season and the playoffs, San Francisco leads the series 1291-1290-17. The Dodgers had led the series on Tuesday morning, but they lost each of the first two games of the series after scoring just one total run.

Los Angeles will hope to salvage a game and tie the series up overall when the teams meet at 3:45 p.m. ET at Oracle Park.

Tyler Glasnow will toe the rubber for the Dodgers, and the Giants will counter with Logan Webb.

Let’s break down this matchup with some odds and lines at DraftKings Sportsbook.

Los Angeles Dodgers at San Francisco Giants prediction, preview

Despite the results of the series so far, Los Angeles has been the better team this season. The Dodgers are tied atop the NL West with the San Diego Padres, and though they’ve lost four of their last five games because their offense has gone cold, they still sit among the leaders in both hitting (an .837 OPS, first by 44 points) and pitching (3.41 ERA, fifth). Individually, Los Angeles has seven hitters with an .850 OPS or better, and Shohei Ohtani, Justin Wrobleski, and Yoshinobu Yamamoto all have ERA’s below 2.5. But San Francisco didn’t win these games by accident, either; it has won five of its last six and has the 11th-lowest ERA. Offensively, the Giants have struggled, ranking just fifth-to-last in OPS, but their coldest hitters might be starting to pick it up. Patrick Bailey and Rafael Devers have both been worth negative WAR, but Bailey provided a decisive blow last night by going deep off of Jack Dreyer, his first homer of the season and the first one allowed by Dreyer.

By raw stats, Glasnow has been the worst of Los Angeles’ four primary starters, as his 3.24 ERA is higher than Yamamoto’s (2.48), Wrobleski’s (1.88), or Ohtani’s (0.38). Obviously, though, that speaks more to the Dodgers’ riches of talent than it does to Glasnow’s, and he also has a better FIP than either Wrobleski (3.02) or Yamamoto (3.17). Advanced stats back up his strong surface-level resume, as he’s combined an 86th percentile strikeout rate with an 81st percentile walk rate, marking the fifth season in the last six in which he’s ranked above average in both strikeout and walk percentage. San Francisco isn’t well-suited to take advantage of his lone weakness, as while he gives up too many hard hits, the Giants rank ninth-to-last in hard-hit percentage and sixth-to-last in barrel rate this season. They whiff very infrequently — signing Luis Arráez in the offseason helped — but they also don’t walk frequently (again, thanks in part to Arráez). The splits also benefit Glasnow; he has a career 2.91 ERA at Oracle Park, and San Francisco has been both much worse at home (.592 OPS; last) and against right-handed pitchers (.624 OPS, third-to-last).

The Giants could make life difficult for the Dodgers’ offense, too. Webb is a much better pitcher than either Landon Roupp or Tyler Mahle, who shut down Los Angeles on Tuesday and Wednesday, as he’s received Cy Young Award votes in each of the past four seasons. Though he’s struggled so far this season, pitching to a 5.10 ERA in his first five starts of the season, he had seven innings of one-run ball in his most recent start at home, and his pitch profile isn’t all that different from last season, when he finished with a 3.22 ERA. Still, even in his best seasons, Webb has been prone to giving up hard hits, and ranking in the 10th percentile in average exit velocity could be disastrous against this high-powered Dodgers offense, which leads the league in that stat. They’ve also been among the league’s best at avoiding ground balls, so they should be well-suited to mitigate Webb’s biggest strength. At least the splits should still be in Webb’s favor overall; he’s been better at home, and Los Angeles has been slightly worse against righties. The Dodgers have been much better on the road, but playing the Washington Nationals and Colorado Rockies away is a different task than dealing with San Francisco’s cool, coastal conditions.

Los Angeles Dodgers at San Francisco Giants pick, best bet

Best Bet: Under 7.5 (-118)

I’m not necessarily buying Los Angeles’ offense being as cold as it has been over the last couple of games, but Glasnow is an excellent pitcher and Webb is much better than his stats have indicated this season. The Dodgers might get a few hard hits off, but eight runs is a high bar when neither starter is particularly likely to give up more than two.

Strong Lean: Tyler Glasnow O17.5 Outs Recorded (-145)

Dave Roberts has been letting his starters stay in the game, with each of Yamamoto, Glasnow, Ohtani, and Wrobleski averaging at least six innings per appearance. Glasnow has not yet failed to complete the sixth inning, and it’s hard to see him doing so tonight, given how frequently the Giants put the ball in play and Los Angeles’ solid defense.