The Red Sox and Orioles play the second game of their three-game series on Saturday, April 25.

Baltimore is a -112 moneyline favorite, while Boston is -108 on DraftKings Sportsbook. The game total is set at over/under eight runs.

Let’s get into a pick and prediction for this Red Sox vs. Orioles game.

Red Sox vs. Orioles prediction, preview

It’s a battle of the aces on Saturday as Garrett Crochet and Trevor Rogers face off in the second game of this three-game series. Unfortunately for those hoping for a pitching duel, neither has been good to start 2026.

After finishing as the runner-up in AL Cy Young voting last season, Crochet has a 7.88 ERA through five starts this year. His first start was stellar: six scoreless innings with three hits and two walks. Since then, it’s been messy. He’s allowed 10 and five earned runs over his past two starts.

In addition to a struggling starter, the Red Sox are on a four-game losing streak and have lost six of their last seven. The opening game of this series was a 10-3 loss on the road. Baltimore’s offense has been active lately, scoring 10, eight, five and seven in the past four games. That could be trouble for Boston, but it’ll also help the Orioles’ starter, who hasn’t been that great.

Rogers has allowed five and four earned runs over the past two games with a 4.08 ERA this season. Like Crochet, Rogers’ first start was great: seven scoreless innings with three hits and four walks.

Red Sox vs. Orioles Pick, Best Bet

The Red Sox are slight underdogs on the road, which is wild to say with Crochet on the mound. This would rarely be the case last season, but 2026 is a different animal.

A struggling starter meets a hot offense at home. Give me Baltimore moneyline.

Best Bet: Baltimore Orioles ML (-112)