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Baltimore Orioles vs. Seattle Mariners prediction, pick for Wednesday 6/17/26
Keagan Smith · 2026-06-18 · via DraftKings Network

Keagan Smith gives you a preview, prediction and pick for today’s game between the Baltimore Orioles and Seattle Mariners on Wednesday’s MLB slate.

The Baltimore Orioles and Seattle Mariners are getting acquainted quite well as of late. These teams played four games against each other in a series just over a week ago and squared off again last night to begin a three-game set. The M’s took that one over the O’s 3-1 behind a two-RBI night from Cal Raleigh. What’ll happen in game two of the series on Wednesday?

Here’s a betting prediction and pick for tonight’s Mariners vs. Orioles matchup courtesy of MLB odds and lines on DraftKings Sportsbook.

Orioles vs. Mariners prediction, preview

Baltimore Orioles

The Orioles seemingly can’t catch a break, falling to 34-40 on the year and now dropping three consecutive games to go 3-7 over their last 10. They produce 4.65 runs per game, good for ninth in the MLB, but they were quiet last night and the pitching has often let the group down. A .723 OPS has ticked upwards in recent weeks and is good for 13th among all teams, and a slash line of .241/.322/.401 is absolutely a pretty decent mark, and those numbers get a slight bump to .247/.329/.415 for an OPS of .744 against right-handed pitching like they’ll face this evening. The Orioles also have 86 home runs on the year with an ISO of .160 and a BABIP of .293. Sure, a 23.7% K% is on the high side, but Baltimore does still maintain an 0.43 BB/K ratio with a BB% of 10.1% to counter it.

RHP Kyle Bradish draws the start tonight with a 3-7 record in 14 tries. He has a 4.30 ERA, 1.57 WHIP and 70 Ks in 73.1 IP. While his strikeout work is a positive, a 12.1% BB% is a tough sell and he gives up lots of barrels, though he does have an 88th-percentile ground-ball rate. The Orioles’ bullpen has an ERA of 4.53, but a 1.34 WHIP and 12.6% K-BB% are both solid enough.

Seattle Mariners

The Mariners got a much-needed win yesterday to snap a couple of back-to-back losses, hopefully allowing them to build a bit of momentum. Seattle is 38-36, 5-5 over its last 10 outings, and has a run differential of +22. The M’s produce 4.24 runs per game with an OPS of .712 that slots in at 18th in the MLB. They slash .237/.317/.395 overall, and another date with a RHP will be welcome here after hitting .245/.325/.417 with a .742 OPS against similar handedness. A .277 BABIP falls in the bottom few teams, but the Mariners are 13th in ISO at .158 and have 94 homers this year, so they can rake. They also have an 0.40 BB/K ratio with a 22.3% K% and a 9.0% BB% as well. The offense is yet to reach its ceiling, but that ceiling does exist.

RHP George Kirby will start tonight after going 5-6 in 14 appearances. He has a 4.07 ERA, 1.31 WHIP and 74 punchouts across 84.0 IP. Kirby brings good fastball velocity at 96.8 mph and excellent chase and ground-ball rates with a 6.0% BB%, with his main weakness a low whiff rate. The Mariners’ bullpen has the sixth-best ERA at 3.43 with a 1.32 WHIP and 13.3% K-BB%.

Orioles vs. Mariners pick, best bet

DraftKings Sportsbook lists the Mariners as favorites with -132 odds on the Moneyline in Seattle tonight. The Orioles have +109 odds to win outright. The total sits at 7.5 combined runs between these two clubs.

Best Bet: Under 7.5 (-112)

This feels like a situation where the under holds some value. Kirby is in the midst of a very solid campaign and comes off a 10-strikeout performance against this same Orioles group in his most recent start, allowing three earned runs in six innings. Bradish leaves a bit to be desired and was shelled for five earned runs on three homers by the Mariners in the last series between these teams, but while his play is up-and-down, the M’s are hitting just .222 with a .638 OPS over the last week in something of a mini-slump. Plus, Randy Arozarena is expected to miss some time due to injury, leaving Seattle without a .291-hitting staple in its batting order and outfield. Yesterday’s game ended with four combined runs and this one could easily wind up 4-3 or lower.