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New York Yankees vs. Baltimore Orioles prediction, pick for Tuesday 5/12/26
Keagan Smith · 2026-05-13 · via DraftKings Network

Keagan Smith gives you a preview, prediction and pick for today’s game between the New York Yankees and Baltimore Orioles on Tuesday’s MLB slate.

An AL East rivalry continues on Tuesday afternoon when the New York Yankees take on the Baltimore Orioles for game two of a three-game set. These teams are trending in opposite directions as the Bronx Bombers are surging while the O’s are falling, but perhaps the latter can change their fortunes here after taking a 3-2 win in the series opener yesterday.

Here’s a betting prediction and pick for Tuesday’s Yankees vs. Orioles matchup courtesy of MLB odds and lines on DraftKings Sportsbook.

Yankees vs. Orioles prediction, preview

New York Yankees

The Yankees remain one of the best teams in baseball with a 26-16 record, but they’re slumping slightly after going 5-5 over their last 10 games and dropping four straight. Now, they’re two games shy of the AL East lead. Still, they’re truly elite at the plate, sitting third in OPS at .771 with a slash line of .237/.331/.440. Sitting second in SLG% gives an idea of just how well the Bronx Bombers are driving the ball, but a .202 ISO leads the MLB and provides an even clearer picture of what makes this lineup so deadly. The Yankees’ 64 homers also lead the sport by a seven-blast margin as well. New York also ranks fourth in BB/K ratio at 0.51 while pacing all teams with an 11.9% BB%. On the other side of the picture, a staff ERA of 3.15 is second best in baseball, as is a 1.15 WHIP. The Yanks are also sixth in K-BB% at 15.6% and fourth in LOB% (75.5%), so gone are the days of this being an offense-only team.

The Yankees will start RHP Will Warren, who’s pitched well across eight starts to a 4-1 record. He holds a 3.46 ERA and 1.20 WHIP, striking out 53 batters across his 41.2 IP. His 30.5% K% comes in at the 91st percentile, while his 6.3% BB% falls in the 82nd percentile.

Baltimore Orioles

The Orioles are just 19-29 overall and have dropped six of their last 10 contests, so things could clearly be going better in Baltimore. The expectation was that perhaps it would be a bounce-back campaign for this franchise, but the results simply haven’t been there. The batting statistics are rather uninspiring, especially given the talent in the lineup. A .697 OPS sits 19th on a slash line of .230/.317/.380. The Orioles’ .150 ISO is also perfectly fine, as are their 43 home runs. The team’s 0.44 BB/K ratio is also around the league average, while a 10.8% BB% ranks fifth. Why then, are the O’s losing so many games despite average-but-not-in-a-bad-way numbers at the plate? The answer is the pitching staff. An ERA of 4.70 ranks fourth worst with a 1.44 WHIP. A 12.0% K-BB% isn’t anything special, and while a poor BABIP of .311 could be called bad luck to an extent, it’s still third worst in the MLB while the team struggles in the field.

Help is on the way for the Orioles on the mound, though. LHP Trevor Rogers returns from IL today and will start after going 2-3 in his six games. He’s racked up a 4.75 ERA and 1.45 WHIP with 27 strikeouts in 30.1 IP, but he was excellent last season and could certainly return to that form.

Yankees vs. Orioles pick, best bet

DraftKings Sportsbook lists the Yankees as -149 Moneyline favorites on the road tonight. The Orioles come in at +123 odds to win outright. The run total also sits at 8.5 combined runs between these sides.

Best Bet: Will Warren to record a win (+160)

Warren has been really solid for the most part in what’s on track to be a career-best season for the third-year pro. He already has four wins in eight starts, one of which came last time out against the Orioles on May 1. In that outing, he went 6.1 innings while allowing just three hits and one walk for one earned run, also striking out nine batters. He looked great in that outing and could certainly follow it up with another excellent performance against an offense that’s hitting just .210 across 11 games this month. The O’s are cold but the Yankees’ bats are still producing with a .260 average in May themselves while slugging a staggering .482. Assuming Warren goes at least five innings, I do like him to pick up the win today as New York bounces back from last night’s loss.