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Chicago Cubs vs. Philadelphia Phillies prediction, pick for MLB on Wednesday 4/22/26
Dan Johnson · 2026-04-23 · via DraftKings Network

Dan Johnson takes you through his preview, prediction, and best bet for today’s baseball game between the Chicago Cubs and the Philadelphia Phillies.

Philadelphia limps into Wrigley at 8-15 on a seven-game skid, while Chicago is 14-9 and riding a seven-game heater that’s turned the park into a pressure cooker again. Tuesday’s 7-4 opener was was another night where the Cubs piled up traffic, controlled the game flow, and still left runs on the table. Below is my preview, prediction, and pick for today’s baseball game between the Chicago Cubs and the Philadelphia Phillies.

Here’s how I’ll play it. I’ll be pumping out these predictions for individual games all season, with plenty of coverage here on DraftKings Network. Follow my handle @dansby_edits for more betting plays.

Cubs vs. Phillies prediction, preview

The structure of this game leans that way before the first pitch is even thrown. Philadelphia is opening with Kyle Backhus, a left-hander with zero starts, just 6.2 innings on the season, a 5.40 ERA, and two home runs already allowed. That’s not a starter—it’s a bridge. And behind that bridge sits a staff carrying a 4.99 ERA and 1.47 WHIP, with the bullpen alone posting a 5.23 ERA and 1.79 WHIP over its last five games, allowing 50 hits and 27 walks in 43.0 innings. Chicago has been getting waves of contact opportunities against a pitching group that hasn’t been able to stop them.

That matters because the Cubs’ offense is operating at a different level right now. Over their last 10 games, they’ve scored 68 runs, hitting .296/.392/.461 with 14 home runs, 52 walks, and 106 hits. That’s sustained pressure, not a two-game spike. The split that matters tonight is even louder: against left-handed pitching over that same stretch, Chicago is batting .333/.416/.547 with eight home runs, 28 RBI, and an OPS just under 1.000. On the season, that split still holds at .274/.366/.451 with an .818 OPS and 38 walks, so this is peak form.

Seiya Suzuki has been crushing lefties at a small sample-size, sitting at .438 with a .526 OBP and a 1.214 OPS in the split, while Nico Hoerner is at .394/.474/.697 with 11 RBI against left-handers and 15 hits with 13 RBI over his last 10 games overall. Michael Busch and the middle of the order keep the line moving, and Tuesday’s box score told the same story: 12 hits, 10 walks, two hit batters, and 17 runners left on base. Seven runs could have easily been nine or ten. That’s what makes this different from a one-night over—it’s repeatable traffic.

Phillies vs. Cubs pick, best bet

Bryce Harper and Kyle Schwarber can still leave the yard, and they already did in the opener. But the team profile hasn’t supported sustained scoring or run prevention. The Phillies are hitting .218/.298/.360 on the season with just 80 runs, and their path to winning games has leaned heavily on isolated damage instead of stacking innings. That’s a problem in a game where Chicago is constantly forcing baserunners and forcing mistakes.

This is why the bet shape matters. Cubs full-game ML is expensive and still leaves room for a weird 5-4 or 6-5 script. First-five angles lean too heavily on a short opener window. The cleanest expression is letting the Cubs offense do what it’s been doing across nine innings against a weak, overextended staff. The volume is there, the split is there, and the matchup is built for it.

Cubs team total over 4.5 (+100). The way it loses is simple: Chicago strands another wave of runners and settles in the three- or four-run range despite the traffic. But the numbers keep pointing to the same outcome—too many baserunners, too many cracks at a vulnerable staff, and eventually enough damage to clear the number.

Cubs 6, Phillies 3

Best bet: Cubs TT o4.5 runs (+100) vs. Phillies

Tail it with me in the DKN Betting Group here!