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MLB Best Bets: Top NRFI props for Friday 5/22/26
Bryan Armetta · 2026-05-22 · via DraftKings Network

Bryan Armetta shares his three favorite MLB no run first inning (NRFI) prop bets on DraftKings Sportsbook for Friday’s slate.

15 games between 30 teams are set for Friday across Major League Baseball. For those looking to cash in quickly on a bet, nothing makes more sense than an NRFI. With that being said, there’s more to this one than meets the eye. Some pitchers thrive early, while others take more time to get settled in than others. Which NRFI picks are worth a closer look today?

Ahead of Friday’s MLB contests, here are three NRFI bets worth placing on DraftKings Sportsbook.

Guardians vs. Phillies NRFI (-140)

Cleveland, per usual, has been buoyed by a stellar pitching staff. It’ll be Gavin Williams taking the mound this evening for the Guardians. Through 61.1 innings of work, the right-hander owns a 3.67 ERA, 1.19 WHIP and 73 strikeouts (10.7 K/9). During his ten starts, the right-hander has allowed a first inning run three different times (70%). Although the Phillies have been playing better as of late, this isn’t an amazing spot for them. Philadelphia’s lineup has posted a .698 OPS against righties, 19th in baseball.

For the home team, it’ll be staff ace Cristopher Sanchez toeing the slab. It’s been another dominant season from the former All-Star. During ten outings, he’s accounted for a 1.82 ERA, 1.20 WHIP and 80 strikeouts (11.2 K/9). At this point, I’m backing the southpaw against just about every lineup in baseball. That’s especially true when it comes to this middling Cleveland offense. The Guardians are averaging the 15th-most runs per game (4.38) this season. They also own a below league-average .377 slugging percentage. That’s bad news against one of the best pitchers on Earth.

Rangers vs. Angels NRFI (-135)

Texas’ chances at contention depend heavily on the health of Jacob deGrom. When he’s on the mound, the two-time Cy Young winner remains an absolute force. This season, he’s delivered a 3.02 ERA, 0.91 WHIP and 61 strikeouts (10.8 K/9) over nine starts. Despite a few shaky outings in May, the veteran isn’t someone I’d be eager to bet against. Tonight, he’ll face an Angels club that’s scored just 16 times over their last five contests. That’s the fifth-worst mark in the league during that time. deGrom has allowed one earned run or less in six of his nine appearances this season.

LA will counter with arguably their most talented hurler, Grayson Rodriguez. The oft-injured righty missed nearly two months due to shoulder inflammation. However, he finally made his season debut on May 17th, getting hammered for seven runs in 3.1 innings against the Dodgers. Although it’s a disappointing performance, the 26-year-old is poised for a better outing this evening. Texas has been a disappointment at the plate, averaging the fifth-fewest runs per game in baseball (3.92). That’s without factoring in the loss of All-Star shortstop Corey Seager (back). To make matters worse, the Rangers have recorded the league’s eighth-worst YRFI rate (24.49%). A clean top of the first feels more than reasonable for Rodriguez on Friday.

Athletics vs. Padres NRFI (-110)

The Athletics will hand the ball this evening to one of their top arms, Jeffrey Springs. While he can be inconsistent, the ninth-year pro has had moments of greatness in 2026. Through 55.0 innings pitched, the southpaw has put up a 3.93 ERA, 1.20 WHIP and 47 strikeouts (7.7 K/9). He’s also been far more effective on the road (3.04 ERA, 1.10 WHIP). The Padres are on the hook for an 18.37% YRFI rate, fourth-worst in the sport. In addition, San Diego has recorded an MLB-worst .586 OPS against lefties.

For all their hitting prowess, the A’s often take some time getting into a groove. Their 24.00% YRFI rate is tied for sixth-lowest in the majors. It’s been the exact opposite story for Walker Buehler, looking to reinvent his career in San Diego. Granted, the veteran has produced mediocre stats (5.01 ERA, 1.36 WHIP). Still, his issue usually comes later in games. The former All-Star has allowed one first inning run over nine starts this season (90%). At cavernous Petco Park, early scoring could be difficult to come by.

Find all your NRFI and YRFI info on the DK Stats Hub! Click here for more!