Washington — Louisianans are voting Saturday in the state's Senate primaries as Sen. Bill Cassidy fights to hold onto his seat. 

A handful of Republicans are facing off Saturday in a competitive primary to win the GOP nomination as Cassidy — a Republican who has occasionally broken with his party — seeks a third term in the Senate. 

Cassidy, 68, was one of seven Senate Republicans who voted to convict Mr. Trump in his impeachment trial after the Jan. 6 attack on the Capitol in 2021. And although he's emphasized his cooperation with the administration in recent years, the president endorsed Rep. Julia Letlow in January, encouraging her to challenge Cassidy for the seat.  

Letlow, 45, became the first Republican woman elected to represent Louisiana in Congress in 2021 after winning a special election for Louisiana's 5th Congressional District following the death of her husband, who died in 2020 from complications related to COVID-19 before he could be sworn into office. She's hammered Cassidy as disloyal to the GOP, claiming Louisiana "shouldn't have to wonder how our senator will vote when the pressure's on."

In addition to his vote to impeach Mr. Trump, Cassidy has been at odds with the administration over Health and Human Services Secretary Robert F. Kennedy Jr.'s leadership, despite delivering the key vote to advance Kennedy's nomination last year. Cassidy, a medical doctor, has broken with the HHS secretary on multiple occasions, including slamming a change to the hepatitis B vaccine schedule for infants and calling for the postponement of key vaccine advisory panel meetings.

While Letlow has accused Cassidy of not being sufficiently conservative, Cassidy has claimed the same about his Trump-backed opponent, pointing to comments she made in 2020 supporting DEI programs in education. And the feuding between the two candidates has appeared to create an opportunity for another Republican — state Treasurer John Fleming, who  previously represented Louisiana in the House and worked in the first Trump administration. 

If no candidate receives a simple majority, the top two vote-getters will go to a runoff on June 27. An Emerson College poll from April indicates that the outcome is likely. 

The contest will likely be viewed as a test of the president's influence. Earlier this month, Mr. Trump's gambit to push Republicans out of the state Senate in Indiana who defied his redistricting efforts was largely successful. Whether the same is true in Louisiana remains to be seen. 

Meanwhile, the Senate Republicans' campaign arm, the National Republican Senatorial Committee, has supported Cassidy. Senate Majority Leader John Thune told reporters Thursday that "Bill Cassidy has been a terrific senator for Louisiana."

"Tim Scott and I at the NRSC, our job is to do what we can to support incumbents," Thune said.
"But obviously the voters of Louisiana are going to make that decision."

On the Democratic side, Nick Albares, a former policy advisor to Gov. John Bel Edwards, Navy veteran Gary Crockett and third-generation farmer Jamie Davis are facing off for their party's nomination. But Louisiana is a solidly red state, where Mr. Trump won 60% of the vote in 2024. And the state last elected a Democrat to the Senate in 2008, making the winner of the GOP primary likely to face a glidepath to the Senate in November's general election. 

Louisiana's Republican Gov. Jeff Landry suspended the state's House primaries in the wake of the Supreme Court decision to strike down the state's congressional map earlier this month, while other races, including the Senate primaries, were set to go on as planned.