Comments come before Marco Rubio’s meeting with Pope Leo XIV at the Vatican on Thursday.

United States Secretary of State Marco Rubio has pushed back on comments that President Donald Trump accused Pope Leo XIV of “endangering Catholics” over his stance on the Iran war, saying his early remarks had been mischaracterised.

“Well, I don’t think that’s an accurate description of what he said,” Rubio told reporters on Tuesday when asked about Trump’s comments that the pope was “endangering a lot of Catholics”.

Rubio said the president’s concern was rooted in the threat Iran could pose to “places that have a lot of Catholics and Christians and others”, and questioned why “anyone would think that it’s a good idea for Iran to ever have a nuclear weapon”.

He also pointed to rising tensions in the Strait of Hormuz, accusing Tehran of “holding the whole world hostage” and endangering commercial shipping.

Trump had earlier criticised the pope in remarks to right-wing radio host Hugh Hewitt, suggesting the pontiff was too soft on Tehran.

“The pope would rather talk about the fact that it’s OK for Iran to have a nuclear weapon, and I don’t think that’s very good,” Trump said.

“I think he’s endangering a lot of Catholics and a lot of people. But I guess if it’s up to the pope, he thinks it’s just fine for Iran to have a nuclear weapon,” he added.

The exchange comes in advance of a meeting between Rubio and Pope Leo XIV at the Vatican on Thursday, which the US ambassador to the Holy See said is expected to be “frank”, underscoring tensions between Washington and the Catholic Church.

“Nations have disagreements, and one way to work through them is through dialogue,” Ambassador Brian Burch said on Tuesday.

“I think the secretary is coming here in that spirit, to have a frank conversation about US policy and engage in dialogue,” he added.

The pope has not said Iran should have nuclear weapons, but has opposed the war, which Trump says is aimed at stopping Tehran’s nuclear programme.

War of words between Trump and Pope Leo

Strains between Trump and Pope Leo began in March after the pontiff spoke out against the war in Iran and criticised the use of Christian rhetoric to justify military action.

The dispute escalated in April when Trump attacked the pope on social media, calling him “weak on crime” and accusing him of aligning with the “radical left”.

Pope Leo later responded during a trip to Algeria, saying he was not afraid and would keep speaking out against the war.

“I will continue to speak out loudly against war, looking to promote ⁠peace, promoting dialogue and multilateral relationships among the states ⁠to look for just ⁠solutions to problems,” he said, speaking in English.

“Too many people are suffering in the world today. Too many innocent people are being killed. And I think someone has to ‌stand ‌up and say there’s a better way.”

Cardinal Pietro Parolin, the Vatican’s top diplomat, said he did not know if Leo would respond to Trump’s latest comments.

“The pope will go ahead on his path, in the sense of preaching ‌the Gospel [and] ⁠peace,” Parolin, the Vatican’s secretary of state, told journalists. He said Leo would speak about peace at every opportunity, “convenient and inconvenient”.

Rubio is also set to meet on Friday with ⁠Italian Prime Minister Giorgia Meloni, who defended the pope, while her defence minister has said the war in Iran puts US leadership at risk.

The pope has also criticised the Trump administration’s hardline immigration policies and called for dialogue between the United States and Cuba, which has faced frequent blackouts linked to US sanctions.