Hi @Nathan Stratton and all,
You need clear guidance here: do not do that unless you have a very compelling reason to.
a) Your hardware is discontinued and past the end of service, which significantly increases the likelihood of component failure.
b) As the number of virtual machines grows, the pmxcfs payload becomes larger and more demanding to synchronize across nodes.
c) Software updates introduce additional complexity and coordination challenges at this scale.
We work with several customers operating at this scale, including those who have tested beyond 32 nodes. None of them found significant value in deploying a single, monolithic cluster. You will be far better off with separate failure domains for fault isolation, simpler management, and easier maintenance.
I always encourage people to ask themselves: "How much of my infrastructure can I tolerate losing if there were an unexpected failure?" If that answer is not 100%, start dividing.
Blockbridge : Ultra low latency all-NVME shared storage for Proxmox - https://www.blockbridge.com/proxmox