Abstract:Exploring molecular energy landscapes and identifying ground-state conformations are central challenges in computational chemistry. However, generating diverse low-energy conformers from molecular graphs remains expensive with traditional physics-based pipelines. Existing learning-based approaches remain fragmented: generative models capture conformational diversity but often lack reliable energy calibration, whereas deterministic predictors focus on a single structure and fail to represent ensemble variability. Here we introduce EnFlow, to our knowledge, the first energy-guided generative framework that couples flow-based conformer generation with explicit energy landscape modeling for joint conformational ensemble generation and ground-state identification. By integrating generative dynamics with a learned energy model, EnFlow guides sampling toward low-energy regions of the conformational landscape, improving structural fidelity under extremely few sampling steps while enabling energy-based ranking of generated conformations. Experiments on GEOM-QM9 and GEOM-Drugs show that EnFlow achieves strong performance in conformer generation and ground-state identification while requiring only 1--2 ODE sampling steps. Single-point GFN2-xTB evaluations further show that the learned energy scores preserve physically meaningful energetic rankings of generated conformations. These results support explicit energy landscape modeling as an effective strategy for low-energy molecular structure discovery through joint modeling of conformational ensembles and their associated energies.
From: Guikun Xu [view email]
[v1]
Sat, 27 Dec 2025 14:00:22 UTC (24,767 KB)
[v2]
Fri, 22 May 2026 12:56:03 UTC (10,397 KB)
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