


























Abstract:Classifying protein topology is essential for deciphering biological function, but progress is held back by the lack of large-scale benchmarks that avoid duplicates and by models that do not scale well. We introduce TEDBench, a large-scale, non-redundant benchmark for protein fold classification constructed from the Encyclopedia of Domains (TED) and Foldseek-clustered AlphaFold structures. We show that on TEDBench, current protein representation learning methods either require very large models or fail to deliver strong performance. To address this challenge, we propose Masked Invariant Autoencoders (MiAE), a self-supervised framework for protein structure representation learning. MiAE uses an extremely high masking ratio of up to 90% with an $\mathrm{SE(3)}$-invariant encoder and a lightweight decoder that reconstructs backbone coordinates from the latent representation and mask tokens. MiAE scales well and outperforms supervised counterparts and state-of-the-art baselines on TEDBench, establishing a strong recipe for protein fold classification. To test transfer beyond AlphaFold structures, we further benchmark on a curated dataset from experimental structures of CATH v4.4. TEDBench is available at this https URL.
| Comments: | Accepted at ICML 2026 (spotlight) |
| Subjects: | Machine Learning (cs.LG); Biomolecules (q-bio.BM); Quantitative Methods (q-bio.QM) |
| Cite as: | arXiv:2605.18552 [cs.LG] |
| (or arXiv:2605.18552v1 [cs.LG] for this version) | |
| https://doi.org/10.48550/arXiv.2605.18552 arXiv-issued DOI via DataCite (pending registration) |
From: Dexiong Chen [view email]
[v1]
Mon, 18 May 2026 15:32:34 UTC (7,937 KB)
此内容由惯性聚合(RSS阅读器)自动聚合整理,仅供阅读参考。 原文来自 — 版权归原作者所有。