In tropical countries with high humidity, air conditioning can account for up to 60% of a building's energy use. For commercial buildings with centralized systems, the efficiency of the chiller plant is vital, and model predictive control provides an effective strategy for optimizing operations through dynamic adjustments based on accurate load predictions. Artificial neural networks are effective for modelling nonlinear systems but are prone to overfitting due to their complexity. Effective feature engineering can mitigate this issue. While weather data are crucial for load prediction, they are often used as raw numerical inputs without advanced processing. Clustering features is a technique that can reduce model complexity and enhance prediction accuracy. Although previous studies have explored clustering algorithms for load prediction, none have applied them to multidimensional weather data, revealing a research gap. This study presents a cooling load prediction model that combines a neural network with Kalman filtering and K-means clustering. Applied to real world data from a commercial skyscraper in Singapore's central business district, the model achieved a 46.5% improvement in prediction accuracy. An optimal chiller sequencing strategy was also developed through genetic algorithm optimization of the predictive load, potentially saving 13.8% in energy. Finally, the study evaluated the integration of thermal energy storage into the chiller plant design, demonstrating potential reductions in capital and operational costs of 26% and 13%, respectively.