Object detection in real-world scenarios remains challenging due to diverse image degradations and heterogeneous object distributions, which significantly hinder the generalization of existing detectors. Conventional approaches, including scene-specific representation learning and end-to-end pipeline design, are inherently limited by their reliance on predefined conditions and lack adaptability to dynamic environments. In this paper, we propose DetAS, an agentic detection framework that formulates object detection as a dynamic decision process. Instead of relying on static pipelines, DetAS leverages a Multimodal Large Language Model (MLLM) as a central agent to adaptively compose detection workflows by selecting from a toolbox of restoration modules and specialized detectors. Specifically, DetAS consists of two key components: Self-Adaptive Image Restoration, which dynamically determines whether and how to enhance images for downstream detection, and Multi-Expertise Detection, which integrates multiple domain-specialized detectors and resolves their predictions through instance-level reasoning. To further improve decision quality under fine-grained conditions, we introduce Self-Evolving Experience Harvesting and extend the framework to DetAS-X, which accumulates node-level decision experience from a small set of annotated data and enables experience-aware reasoning during inference. This mechanism allows the system to progressively refine its decision policy and adapt to diverse real-world scenarios. Extensive experiments on six challenging benchmarks demonstrate that DetAS-X significantly outperforms existing MLLM-based detectors, achieving an average improvement of 28.36% in F1 score, with up to 37.01% gain on DarkFace. These results demonstrate the promise of agentic detection and establish a solid foundation for its application in complex and dynamic environments.