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Hacker News - Newest: "LLM"

GitHub - lechmazur/position_bias: A benchmark for testing whether LLM judges keep the same preference when two lightly edited versions of the same story are shown in opposite orders. Flex routing (EU and EFTA) Dark Factories: Retooling for LLM Velocity Ask HN: What would be the impact of a LLM output injection attack? GitHub - AronDaron/dataset-generator: No-code desktop app for generating high-quality synthetic datasets to fine-tune LLMs — plan-then-execute pipeline, LLM-as-judge, HuggingFace upload. I thought I had a bug GitHub - Oaklight/llm-rosetta: Production-ready LLM API translation layer for Python — bidirectional conversion between OpenAI, Anthropic & Google formats via hub-and-spoke IR. Optional API gateway. Streaming & non-streaming. Zero core deps. Contributions welcome! GitHub - browser-use/browser-harness: Self-healing browser harness that enables LLMs to complete any task. GitHub - moeen-mahmud/remen: Remen turns thoughts into something you can return to Analyzing 156 LLM Launch Posts on Hacker News ChatGPT vs Gemini vs Claude: The Best LLM Subscription You Should Buy GitHub - salaamalykum/quran-semantic-search: High-density RAG Semantic Search Engine & Quran Corpus (GEO/SEO Architecture) GitHub - NVIDIA/TensorRT-LLM: TensorRT LLM provides users with an easy-to-use Python API to define Large Language Models (LLMs) and supports state-of-the-art optimizations to perform inference efficiently on NVIDIA GPUs. TensorRT LLM also contains components to create Python and C++ runtimes that orchestrate the inference execution in a performant way. The State of LLM Bug Bounties in 2026 Operational Readiness Criteria for Tool-Using LLM Agents Meshcore: Architecture for a Decentralized P2P LLM Inference Network How an LLM becomes more coherent as we train it GitHub - seetrex-ai/laimark GitHub - Jossifresben/BibCrit: AI-assited biblical textual criticism GitHub - wastedcode/memex: File system based wiki, maintained by Claude 99helpers.com GitHub - cliver-project/AITrigram GitHub - unbody-io/adapt: A self-evolving memory layer for AI agents. GitHub - hb20007/awesome-gen-ai-fails: A list of incidents where reliance on generative AI and LLMs resulted in harm to companies, individuals, or society GitHub - nevenkordic/localmind: Run any local LLM with persistent memory and context. CLI agent over Ollama with SQLite-backed hybrid recall. No cloud. Ask HN: What are the machine requirements for a LLM like Llama-3.1-8B? Faster LLM Inference via Sequential Monte Carlo grpo explained: group relative policy optimization for llm finetuning - cgft Stop comparing price per million tokens: the hidden LLM API costs · TensorZero Andrej Karpathy's LLM Wiki Is a Bad Idea GitHub - GG-QandV/mnemostroma: Offline RAM-first cognitive leer/coprocessor for AI agents and robotics. Solves "Context Abandonment" with 20-80ms latency using a dual-thread biomimetic memory architecture (ONNX + SQLite WAL). mempalace/agent at agent · skorotkiewicz/mempalace GitHub - Nyquest-ai/nyquest-rust-fullstack-pub: Nyquest — Semantic Compression Proxy for LLMs. 350+ rules, local LLM stage, 15-75% token savings. Full Rust stack. GitHub - TheoV823/mneme: Enforce architectural decisions in AI-assisted development. GitHub - klemenvod/TokenBrawl: A 1v1 Bomberman-style game where two LLM agents play autonomously against each other. No human plays — you watch the AIs fight. Each agent receives a text description of the board state, reasons about it, and outputs a move as JSON. The game engine executes it. Introducing the Common AI Provider: LLM and AI Agent Support for Apache Airflow Power Circuit AI: Designing Power Electronic Circuits for Motor Drives with Generative Artificial Intelligence Ask HN: How to program with IDE and LLM on CPU locally? Show HN: Agent-cache – Multi-tier LLM/tool/session caching for Valkey and Redis Bonsai 1-bit WebGPU - a Hugging Face Space by webml-community The LLM Fallacy: Misattribution in AI-Assisted Cognitive Workflows Ask HN: Simple tooling for local LLM code critique without IDE integration? Charts-of-Thought: Enhancing LLM Visualization Literacy (PDF, 2026) GitHub - Mesh-LLM/mesh-llm: Distributed AI/LLM for the people. Share compute privately or publicly to power your agents and chat. 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Open the Black Box with the Arthur Engine Milla Jovovich's New Open Source LLM Memory App and the Dark Code Problem Your intuition of LLM token usage might be wrong Show HN: Bloomberg Terminal for LLM ops – free and open source GitHub - 0xchamin/mcptube: Transform YouTube videos into a compounding knowledge base with transcripts, vision analysis, and agentic search. Works as an MCP server for Claude, Copilot & more. Show HN: Open KB: Open LLM Knowledge Base Your LLM is a compiler, not a runtime GitHub - sapountzis/Unslop: A Web Feed That Deserves You crates.io: Rust Package Registry Beyond Karpathy's LLM-Wiki: The Necessity of Cognitive Governance GitHub - amitshekhariitbhu/llm-internals: Learn LLM internals step by step - from tokenization to attention to inference optimization. GitHub - parallem-ai/parallem: An expressive library for running agents with the Batch API. GitHub - stfurkan/pi-llm LLM-Wiki Show HN: Formal – Formal verification for AI-generated code using Lean 4 LRTS – Regression testing for LLM prompts (open source, local-first) LLM Wiki Skill: Build a Second Brain with Claude Code and Obsidian I built an LLM Wiki and RAG solution: here's a demo for a security KB The biggest advance in AI since the LLM Predict-Rlm: The LLM Runtime That Lets Models Write Their Own Control Flow the-synthetic-library/the-synthetic-mind at main · joshferrer1/the-synthetic-library GitHub - yisding/reviewwiggum GitHub - Donnyb369/mcp-spine: Context Minifier & State Guard — Local-first MCP middleware proxy GitHub - Beledarian/wgpu-llm: A from-scratch LLM inference engine that uses wgpu (the cross-platform WebGPU implementation) to dispatch WGSL compute shaders for every math operation a Transformer needs. No CUDA. No Python. No massive framework dependencies. Just Rust, raw shaders, and your GPU. GitHub - anitiue/Hindsight: An experience-driven self-improvement framework for LLM agents — 基于经验的 LLM Agent 自我改进框架 GitHub - stef41/lmscan: 🔍 Detect AI-generated text and fingerprint which LLM wrote it. Open-source GPTZero alternative. Zero dependencies, works offline. GitHub - alainnothere/AmdPerformanceTesting: Amd Performance Testing Ask HN: Is a purely Markdown-based CRM a terrible idea? Optimized for LLM agents Context Engineering - LLM Memory and Retrieval for AI Agents | Weaviate little_helper_tui/letter.md at main · sleepyeldrazi/little_helper_tui GitHub - EvanZhouDev/umr: The Unified Model Registry for all your local AI apps. GitHub - JordanCT/VigIA-Orchestrator Your Agent Is Mine: Measuring Malicious Intermediary Attacks on the LLM Supply Chain A Taxonomy of RL Environments for LLM Agents Llama LLM Network Feture GitHub - genedeng-ca/ai-mac-migration: AI-powered Mac-to-Mac migration tool - replace Apple Migration Assistant with intelligent, selective transfer using local LLMs GitHub - lunargate-ai/gateway: High-performance self-hosted AI gateway (OpenAI-compatible) with routing, retries, and streaming GitHub - AuthBits/webmcp: A lightweight, prompt-driven MCP web research server for high-quality LLM powered information extraction. Externalization in LLM Agents: A Unified Review of Memory, Skills, Protocols and Harness Engineering Springdrift: An Auditable Persistent Runtime for LLM Agents with Case-Based Memory, Normative Safety, and Ambient Self-Perception High-Stakes Personalization: Rethinking LLM Customization for Individual Investor Decision-Making From Static Templates to Dynamic Runtime Graphs: A Survey of Workflow Optimization for LLM Agents HUOZIIME: An On-Device LLM-enhanced Input Method for Deep Personalization TIDE: Token-Informed Depth Execution for Per-Token Early Exit in LLM Inference Characterizing WebGPU Dispatch Overhead for LLM Inference Across Four GPU Vendors, Three Backends, and Three Browsers LLM Targeted Underperformance Disproportionately Impacts Vulnerable Users
Can a General LLM Diagnose a DICOM Slice? A 10-Case Public Benchmark
2026-04-16 · via Hacker News - Newest: "LLM"
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4 min read Updated April 16, 2026 10-case benchmark 7 CT + 3 MRI

The answer is absolutely fucking not. The industry is optimizing the wrong layer. A general multimodal LLM is not replacing a radiologist any time soon, and even a domain-trained model is not a substitute for clinical responsibility. The useful role is narrower: review, evidence gathering, drafting, and workflow support. The real question is operational cost: large DICOM studies, expensive inference, strict reliability, and regulated data handling.

Published April 15, 2026 · Updated April 16, 2026

This is a real benchmark, but it is still small. It is not a clinical validation study and it does not support diagnostic claims. It answers one narrow question: how far can a general multimodal model go on a public single-slice DICOM task before confidence stops matching reality?

What I Tested

I used 10 public Pacsbin teaching cases: 7 CT or CTA studies and 3 MRI studies. For each case I selected one pathology-bearing key image, downloaded the linked DICOM instance, rendered it with the case page's own window settings, and asked the model for the single most likely diagnosis visible on that slice. The score was simple. A response was a match, a partial, or a miss.

What Happened

The result was weak. Strict top-1 accuracy was 3/10. Two more answers were directionally useful but incomplete, which brought the softer score to 5/10. The misses were not random. The model often locked onto a structure that was visually obvious but clinically secondary, then built a confident story around the wrong disease. The ugliest example was acute appendicitis misread as bilateral osteitis condensans ilii at 0.89 confidence. It sounded convincing. It was obviously wrong.

What Changed In The Follow-up

The original public benchmark used the Codex CLI path on gpt-5.4. The follow-up harness also included direct OpenAI API testing, and the published review-pipeline comparison used gpt-4.1-mini. The new workflow was ROI-first and stopped trusting one answer. One pass made the first call, another proposed a competing explanation, and a few checks tried to decide which story held up better. That made the output easier to inspect and audit. It still did not solve the core problem.

Animated DICOM workbench showing region selection, the built-in review panel, and the structured proof-style result flow.
The follow-up workflow pass: ROI-first selection, a built-in side panel, and a structured review object.

The second benchmark made the lesson sharper. ROI guidance helped. Extra review logic helped the system explain itself. But the review pipeline still did not beat the same-run finder baseline on the fairest comparison. Reasoning improved faster than perception.

Operational Cost

Medical AI becomes an operational problem very quickly. A DICOM study is not a neat image file. It can span hundreds or thousands of instances and reach gigabytes. In many regulated industries, public cloud is not a free choice, so pushing that data through laptops, temp folders, and shared drives is slow, expensive, and hard to control.

A concrete example is a worker pod reading a large study from mounted storage. If the network share stalls or drops, the worker can fail in the middle of processing. In a script-like setup, that often leaves the case hanging in an unclear state. In a fault-tolerant clustered runtime, the pod can die, restart, or be rescheduled while the case state stays outside the process in a queue or status store. The same applies to scale: metadata workers and heavy GPU inference workers can scale separately instead of fighting for one machine. That is the real value. Not that failures disappear, but that storage faults, restarts, and load spikes stop breaking the whole pipeline.

This matters even more because medical environments are highly regulated, often tied to legacy PACS and hospital software, and usually built on a fragmented stack of old viewers, file shares, vendor gateways, and custom interfaces. That is why localhost is the wrong center of gravity. The safest path is to keep files, models, and workers inside the controlled runtime and use the browser only as the control surface.

For users, that changes daily work. They stop moving data through their laptop just to inspect or patch something inside a pod. The browser becomes the control surface and the runtime stays where the files and workers already live. That means fewer broken local environments, fewer kube-context mistakes, fewer copied secrets, and less context switching between terminal, editor, and file browser. It also makes failure handling much safer: atomic saves, snapshots, rollbacks, live watch streams, and controlled transfers replace a lot of “scp and hope.” A related version of the same argument shows up in the previous post on Portal Long-Term Memory.

Conclusion

The conclusion is simple. The real bottleneck is not the radiologist, and replacing radiologists with LLMs is not a credible near-term goal. The model is not the product. The operational surface is. In this benchmark the model was sometimes useful, often articulate, and still wrong too often to earn diagnostic trust. The realistic opportunity is replacing the brittle legacy software stack around the reader with better systems for review, evidence, drafting, and workflow.

If you want to inspect the work, the evaluation script, the raw benchmark JSON, and the review-pipeline comparison JSON are all public.