“Supergirl” and “Jackass: Best and Last” fly into theaters this weekend, but neither will pose a threat to “Toy Story 5” on box office charts.

“Supergirl” is expected to earn $47 million to $50 million in its debut, while “Jackass” is targeting a launch around $10 million to $12 million from 2,800 theaters. “Toy Story 5” will tower above those titles in North America with the animated Pixar sequel estimated to bring in $80 million to $90 million in its sophomore outing.

“Supergirl” is the follow-up to last summer’s “Superman,” which rebooted the Warner Bros. DC Universe under the direction of James Gunn and Peter Safran. That film, starring David Corenswet as the Man of Steel, ignited to $125 million and ended its run with $618 million, a promising enough tally amid the overall decline of comic book adaptations. While “Superman” had the benefit of centering on one of the most recognizable heroes of all time, “Supergirl” focuses on his cousin Kara Zor-El, who isn’t quite as recognizable to the average moviegoer. “Supergirl” carries a price tag of $170 million, not including worldwide marketing expenses. Although the intergalactic adventure was less expensive than “Superman,” which cost $225 million, “Supergirl” needs to resonate with audiences young and old to justify its hefty budget.

Milly Alcock plays Supergirl, who travels through the cosmos with her trusty pup Krypto the Superdog. When she encounters an alien girl named Ruthye, she reluctantly joins her on a quest for vengeance and justice. Craig Gillespie, best known for “I, Tonya” and “Cruella,” directed the film from a script by Ana Nogueira (“The Vampire Diaries”).

“Jackass: Best and Last,” starring Johnny Knoxville, Steve-O, Wee Man and their other daredevil friends, is positioned as the fifth and final installment in a comedy series that’s all about risking life, limb and dignity. Unless “Best and Last” wildly exceeds expectations, it will rank as the lowest opening in the franchise. The prior installment, 2022’s “Jackass Forever,” had a much bigger $23 million debut and ended up with $80 million globally. However, “Jackass 5” cost just $10 million to produce, so it doesn’t need to earn much to turn a theatrical profit. “Jackass” began as a television series on MTV more than two decades ago and continued with four other R-rated reckless prank sequels. This installment could be tracking to a lower start because it’s not entirely original; the film is a compilation of new and old stunts and skits.

“Toy Story 5” should continue a mighty streak for animated sequels, as well as a bustling popcorn season. Although original animation has been challenged since the pandemic, follow-ups like 2024’s “Inside Out 2” and 2025’s “Zootopia 2” were among the year’s highest-grossing releases. “Toy Story 5” will follow suit, with ticket sales at $176 million domestically and $328 million after just a few days in theaters.

Hollywood is having its hottest summer since COVID, with revenues just 1.8% behind 2019, the last pre-pandemic year, according to Rentrak. Thanks to original sleeper hits like “Obsession” and “Backrooms” as well as new installments in reliable franchises such as “The Devil Wears Prada 2” and “Scary Movie,” the four-month stretch is expected to eclipse the once-reliable $4 billion milestone. Only once, during the glory days of “Barbenheimer” in 2023, have domestic revenues hit the hoped-for benchmark.